DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Vanmierlo T et al. Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. 2010 J. Alzheimers Dis. pmid:20061631
Pihlajamäki J et al. Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding. 2010 Metab. Clin. Exp. pmid:20015521
Strandberg TE et al. Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. 2010 Atherosclerosis pmid:19962145
Wei D et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. 2010 Diabetes pmid:19933995
Kim JH et al. Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. 2010 J. Neurochem. pmid:19860851
Gylling H et al. Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. 1991 Metab. Clin. Exp. pmid:1984567
van Himbergen TM et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19834104
Matiz C et al. Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? 2009 Pediatr Rheumatol Online J pmid:19814780
Moraes EA et al. Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. 2010 Anim. Reprod. Sci. pmid:19733986
Nissinen MJ et al. Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men. 2010 Nutr Metab Cardiovasc Dis pmid:19695854
Singh P et al. Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis. 2009 Biochim. Biophys. Acta pmid:19616511
Drzewińska J et al. [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. 2009 Postepy Hig Med Dosw (Online) pmid:19597241
Matthan NR et al. Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. 2010 J. Lipid Res. pmid:19578163
Mirza R et al. Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice. 2009 Am J Dermatopathol pmid:19542918
Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Zalata A et al. Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient. 2010 Int. J. Androl. pmid:19490187
Kuehnle K Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). 2009 Neurochem. Res. pmid:19475506
Matthan NR et al. Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. 2009 J. Lipid Res. pmid:19436064
Stevenson J and Brown AJ How essential is cholesterol? 2009 Biochem. J. pmid:19426142
Peri A et al. New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. 2009 Front Neuroendocrinol pmid:19351544