DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Paoletti P Desmosterol in CSF. 1981 Neurology pmid:7194986
Peri A and Serio M Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1. 2008 Neuropsychiatr Dis Treat pmid:19043524
Lee CS et al. Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. 2006 Neuroreport pmid:16407768
Kazkayasi I et al. Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats. 2016 Neurosci. Lett. pmid:27639960
Peri A et al. Membrane cholesterol as a mediator of the neuroprotective effects of estrogens. 2011 Neuroscience pmid:21396986
Ramos SC et al. The role of soluble fiber intake in patients under highly effective lipid-lowering therapy. 2011 Nutr J pmid:21810257
Brouwers MC et al. Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia. 2013 Nutr Metab Cardiovasc Dis pmid:23333725
Miettinen TA et al. Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study. 2009 Nutr Metab Cardiovasc Dis pmid:19185477
Nissinen MJ et al. Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men. 2010 Nutr Metab Cardiovasc Dis pmid:19695854
Matiz C et al. Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? 2009 Pediatr Rheumatol Online J pmid:19814780
Tammi A et al. Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study. 2001 Pediatr. Res. pmid:11726725
Pasanen MK et al. Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate. 2008 Pharmacogenet. Genomics pmid:18794729
Khanavi M et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. 2012 Pharmacogn Mag pmid:22438665
Nasir M et al. Sterols from the red algae, Gracilaria salicornia and Hypnea flagelliformis, from Persian Gulf. 2011 Pharmacogn Mag pmid:21716930
Vanmierlo T et al. Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. 2011 Plant Foods Hum Nutr pmid:21431910
Niemelä PS et al. Assessing the nature of lipid raft membranes. 2007 PLoS Comput. Biol. pmid:17319738
Stottmann RW et al. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. 2011 PLoS Genet. pmid:21912524
Bieghs V et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. 2012 PLoS ONE pmid:22470565
Ciufo LF et al. Characterisation of a desmosterol reductase involved in phytosterol dealkylation in the silkworm, Bombyx mori. 2011 PLoS ONE pmid:21738635
Cheng D et al. Lipid pathway alterations in Parkinson's disease primary visual cortex. 2011 PLoS ONE pmid:21387008