DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Kobayashi M and Mitsuhashi H Marine sterols. V. Isolation and structure of occelasterol, a new 27-norergostane-type sterol, from an annelida, Pseudopotamilla occelata. 1974 Steroids pmid:4370183
Dennick RG et al. Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. 1974 J. Neurochem. pmid:4854410
Bleau G and VandenHeuvel WJ Desmosteryl sulfate and desmosterol in hamster epididymal spermatozoa. 1974 Steroids pmid:4423229
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Arnold A et al. Triparanol-induced desmoterol accumulation in clofibrate-effected hypocholesterolemia. 1974 Sep-Oct Atherosclerosis pmid:4416741
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Bleau G et al. Desmosteryl sulphate of hamster spermatozoa, a potent inhibitor of capacitation in vitro. 1975 J. Reprod. Fertil. pmid:1127634
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Ochi K et al. Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. 1977 Steroids pmid:611642
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Legault Y et al. 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. 1978 Steroids pmid:734699
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Chau IY and Geyer RP The effects of serum albumin and phospholipid on sterol excretion in tissue culture cells. 1978 Biochim. Biophys. Acta pmid:687659
Evans RW and Tinoco J Monolayers of sterols and phosphatidylcholines containing a 20-carbon chain. 1978 Chem. Phys. Lipids pmid:719817
Doi O and Endo A Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. 1978 Jpn. J. Med. Sci. Biol. pmid:732030
Hansbury E and Scallen TJ Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. 1978 J. Lipid Res. pmid:690514
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors in cerebrospinal fluid. 1978 Nov-Dec Ann. Clin. Lab. Sci. pmid:736510
Francisco C et al. Side chain-hydroxylated sterols of the red alga Asparagopsis armata: significant products or artifacts due to autoxidation? 1979 Steroids pmid:494359
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
Gibbons GF and Pullinger CR Utilization of endogenous and exogenous sources of substrate for cholesterol biosynthesis by isolated hepatocytes. 1979 Biochem. J. pmid:426772
Rosenblum ER et al. Effect of 20,25-diazacholesterol on viability and steroid synthesis capability of cultured chick embryo pectoral muscle cells. 1979 Biochem. Biophys. Res. Commun. pmid:572680