DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Johnson RC and Shah SN Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. 1974 Arch. Biochem. Biophys. pmid:4460877
Kobayashi M and Mitsuhashi H Marine sterols. V. Isolation and structure of occelasterol, a new 27-norergostane-type sterol, from an annelida, Pseudopotamilla occelata. 1974 Steroids pmid:4370183
Smith AG and Goad LJ Sterol biosynthesis by the sea urchin Echinus esculentus. 1974 Biochem. J. pmid:4441383
Ramsey RB and Davison AN Steryl esters and their relationship to normal and diseased human central nervous system. 1974 J. Lipid Res. pmid:4363969
Parks LW et al. Sterol transmethylation during aerobic adaptation of yeast. 1974 Eur. J. Biochem. pmid:4598750
Morisaki M et al. Nutritional effect of possible intermediates of phytosterol dealkylation in the silkworm, Bombyx mori. 1974 Steroids pmid:4421556
Watson KC and Kerr EJ Sterol structural requirements for inhibition of streptolysin O activity. 1974 Biochem. J. pmid:4451554
Dennick RG et al. The occurrence of desmosterol in neuronal and glial fractions from developing rat brain. 1974 FEBS Lett. pmid:4213464
Brennan PJ et al. The lipids of fungi. 1974 Prog Chem Fats Other Lipids pmid:4610639
Croce CM et al. Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts. 1974 Proc. Natl. Acad. Sci. U.S.A. pmid:4359325
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Dasgupta SK et al. New preparation of desmosterol. 1974 J. Org. Chem. pmid:4853344
Fumagalli R et al. [Desmosterol test in the diagnosis of recurrent brain neoplasms]. 1973 May-Jun Acta Neurol (Napoli) pmid:4732487
Imai Y and Shimamoto K Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. 1973 Jan-Feb Atherosclerosis pmid:4696738
Peter JB and Fiehn W Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. 1973 Science pmid:4265797
Johnson RC and Shah SN Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. 1973 Biochem. Biophys. Res. Commun. pmid:4741538
Fleisher JH et al. Cholesterol in cerebrospinal fluid of brain tumor patients. 1973 Life Sci. pmid:4358663
Jurgelski W et al. Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis. 1973 Brain Res. pmid:4798641
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Marton LJ et al. Faliure to demonstrate desmosterol in spinal fluid of brain tumor patients. 1973 Arch. Neurol. pmid:4345665