DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stranberg TE et al. | Associations of fasting blood glucose with cholesterol absorption and synthesis in nondiabetic middle-aged men. | 1996 | Diabetes | pmid:8635649 |
| Likhodii SS and Cunnane SC | Utilization of carbon from dietary polyunsaturates for brain cholesterol synthesis during early postnatal development in the rat: a 13C NMR study. | 1995 | Magn Reson Med | pmid:8598807 |
| Abernethy DR and Azarnoff DL | Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. | 1977 | Biochem. Pharmacol. | pmid:849344 |
| Gibbons GF and Pullinger CR | Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. | 1977 | Biochem. J. | pmid:849287 |
| Lin DS et al. | Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. | 1993 | J. Lipid Res. | pmid:8468532 |
| Awano M et al. | Lipid composition of hamster epididymal spermatozoa. | 1993 | J. Reprod. Fertil. | pmid:8107019 |
| Zeeck E et al. | Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea. | 1994 | Steroids | pmid:8073448 |
| Yagi T et al. | Stereochemistry of hydrogen addition to C-25 of desmosterol by sterol-delta 24-reductase of rat liver homogenate. | 1994 | Chem. Pharm. Bull. | pmid:8004717 |
| Jurevics H and Morell P | Cholesterol for synthesis of myelin is made locally, not imported into brain. | 1995 | J. Neurochem. | pmid:7830084 |
| Lewis D et al. | Enzyme inhibition during the conversion of squalene to cholesterol. | 1995 | Steroids | pmid:7482633 |