DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

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Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

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Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


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Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Sion B et al. Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography. 2001 J Chromatogr A pmid:11762778
Hoenig MR et al. The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. J Clin Lipidol pmid:21392722
Shay CM et al. Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. 2009 J Diabetes pmid:20827426
Sheriff DS and Ali EF Perspective on plasma membrane cholesterol efflux and spermatozoal function. 2010 J Hum Reprod Sci pmid:21209749
Soh J et al. Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. 2011 J Nutr Metab pmid:21437188
Turi JS et al. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells IV: Uptake and release kinetics of sterols. 1975 J Pharm Sci pmid:1170314
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Johnston JJ et al. Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. 2003 J. Agric. Food Chem. pmid:12502398
Wisniewski T et al. Alzheimer's disease: brain desmosterol levels. 2013 J. Alzheimers Dis. pmid:23042211
Vanmierlo T et al. Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. 2010 J. Alzheimers Dis. pmid:20061631
Javitt NB Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing. 2013 J. Alzheimers Dis. pmid:23455994
Rodgers MA et al. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. 2012 J. Am. Chem. Soc. pmid:22480142
Chen SM et al. Letter: Stereospecificity in the conversion of fucosterol 24,28-epoxide to desmosterol in the silkworm, Bombyx mori. 1975 J. Am. Chem. Soc. pmid:1165366
Rajaratnam RA et al. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. 2000 J. Am. Coll. Cardiol. pmid:10758959
Buffone MG et al. High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. 2009 Sep-Oct J. Androl. pmid:19269935
Albers-Schönberg G et al. Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. 1981 J. Antibiot. pmid:7275832
Feio CA et al. Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. 2012 J. Atheroscler. Thromb. pmid:22139433
Mutka AL et al. Secretion of sterols and the NPC2 protein from primary astrocytes. 2004 J. Biol. Chem. pmid:15355983
Leonard DA and Chen HW Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. 1984 J. Biol. Chem. pmid:6425279
AVIGAN J and STEINBERG D Studies of cholesterol biosynthesis. III. The desmosterol reductase system in liver. 1961 J. Biol. Chem. pmid:13863405
AVIGAN J et al. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. 1960 J. Biol. Chem. pmid:13685286
STOKES WM et al. Sterol metabolism. I. The occurrence of desmosterol (24-dehydrocholesterol) in rat skin and its conversion in vivo to cholesterol. 1958 J. Biol. Chem. pmid:13549424
Megha O et al. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. 2006 J. Biol. Chem. pmid:16735517
Ener MA and Frantz ID Chemical synthesis of delta 7,24-(3alpha-3H)cholestadien-3beta-ol and its conversion to cholesterol in the rat. 1973 J. Biol. Chem. pmid:4355504
FISH WA et al. Metabolism of cholesterol in the chick embryo. III. Localization and turnover of desmosterol (24-dehydrocholesterol). 1962 J. Biol. Chem. pmid:13893200
Yang C et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. 2006 J. Biol. Chem. pmid:16857673
Steinberg D Chance and serendipity in science: two examples from my own career. 2011 J. Biol. Chem. pmid:21908608
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Pentchev PG et al. The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. 1986 J. Biol. Chem. pmid:3949747
Ohyama Y et al. Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. 2006 J. Biol. Chem. pmid:16321981
Kiyotake R et al. Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. 2015 J. Biol. Chem. pmid:26296894
Vainio S et al. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. 2006 J. Biol. Chem. pmid:16249181
Clejan S and Bittman R Distribution and movement of sterols with different side chain structures between the two leaflets of the membrane bilayer of mycoplasma cells. 1984 J. Biol. Chem. pmid:6706946
Jansen M et al. Cholesterol substitution increases the structural heterogeneity of caveolae. 2008 J. Biol. Chem. pmid:18353778
James MJ and Kandutsch AA Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures. 1979 J. Biol. Chem. pmid:468837
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643
Hoenig MR et al. Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin. 2010 J. Cardiovasc. Pharmacol. pmid:20625310
Burger BV et al. Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus. 2001 J. Chem. Ecol. pmid:11504028
Martin-Creuzburg D and Von Elert E Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. 2004 J. Chem. Ecol. pmid:15139303
Fujimoto Y et al. Studies on steroids. Part XXIX. Synthesis of allenic analogues fucosterol and desmosterol. 1975 J. Chem. Soc. Perkin Trans. I pmid:1239449
Herz JE and Cruz Montalvo S Fluorinated sterols. 1. 26,26,26,27,27,27-Hexafluorodesmosterol. 1973 J. Chem. Soc. Perkin Trans. I pmid:4795247
Ikan R et al. Synthesis of steroidal cyclopropanes. 1972 J. Chem. Soc. Perkin Trans. I pmid:4674538
Amaral C et al. Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:20630811
Saraiva D et al. Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22088355
Ahmida HS et al. Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16807145
Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Connor WE et al. Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. 1997 J. Clin. Endocrinol. Metab. pmid:9177405
Luciani P et al. Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. 2004 J. Clin. Endocrinol. Metab. pmid:15001630
GOODMAN DS et al. The in vitro metabolism of desmosterol with adrenal and liver preparations. 1962 J. Clin. Invest. pmid:13949087
GOODMAN DS et al. The metabolism of desmosterol in human subjects during triparanol administration. 1962 J. Clin. Invest. pmid:13900301
Tabas I et al. The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction. 1989 J. Clin. Invest. pmid:2592557
Moghadasian MH et al. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. 2002 J. Clin. Pathol. pmid:12401826
Simonen P et al. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. 2011 J. Hepatol. pmid:20947198
de Sain-van der Velden MG et al. Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. 2008 J. Inherit. Metab. Dis. pmid:18949577
Simonen P et al. Desmosterol accumulation in users of amiodarone. 2018 J. Intern. Med. pmid:28861933
Mirza R et al. DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis. 2006 J. Invest. Dermatol. pmid:16410790
Luu W et al. Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. 2014 J. Lipid Res. pmid:24363437
Lütjohann D et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. 2002 J. Lipid Res. pmid:12091492
Matthan NR et al. Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. 2009 J. Lipid Res. pmid:19436064
Matthan NR et al. Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. 2010 J. Lipid Res. pmid:19578163
Ramsey RB and Davison AN Steryl esters and their relationship to normal and diseased human central nervous system. 1974 J. Lipid Res. pmid:4363969
Chevy F et al. Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. 2002 J. Lipid Res. pmid:12177163
Pullinger CR and Gibbons GF The relationship between the rate of hepatic sterol synthesis and the incorporation of [3H]water. 1983 J. Lipid Res. pmid:6644182
Meljon A et al. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. 2012 J. Lipid Res. pmid:22891291
Nes WR et al. Steric effects at C-20 and C-24 on the metabolism of sterols by Tetrahymena pyriformis. 1981 J. Lipid Res. pmid:6793681
Pihlajamäki J et al. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. 2004 J. Lipid Res. pmid:14657199
Phillips JE et al. Basis for rapid efflux of biosynthetic desmosterol from cells. 1998 J. Lipid Res. pmid:9831635
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Björkhem I et al. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. 1987 J. Lipid Res. pmid:3681138
Connor WE et al. Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm. 1998 J. Lipid Res. pmid:9684743
Svoboda JA and Thompson MJ Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations. 1967 J. Lipid Res. pmid:14564725
Long TT et al. The sources of rat biliary cholesterol and bile acid. 1978 J. Lipid Res. pmid:712246
CHOBANIAN AV and HOLLANDER W TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY. 1965 J. Lipid Res. pmid:14280470
McDonald JG et al. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. 2012 J. Lipid Res. pmid:22517925
Andreyev AY et al. Subcellular organelle lipidomics in TLR-4-activated macrophages. 2010 J. Lipid Res. pmid:20574076
Lin DS et al. Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. 1993 J. Lipid Res. pmid:8468532
Berge KE et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. 2002 J. Lipid Res. pmid:11893785
Goyal S et al. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. 2014 J. Lipid Res. pmid:25017465
Sato Y et al. Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. 2012 J. Lipid Res. pmid:22203775
Bentzen CL and Brendel K Synthesis of [24, 25-3H]cholesterol: a new substrate for determining the rate of cholesterol side chain oxidation. 1979 J. Lipid Res. pmid:438651
Gylling H et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. 2004 J. Lipid Res. pmid:15175352
Saucier SE et al. Oxygenation of desmosterol and cholesterol in cell cultures. 1990 J. Lipid Res. pmid:2090711
Matthan NR et al. Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL. 2003 J. Lipid Res. pmid:12562840
Hansbury E and Scallen TJ Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. 1978 J. Lipid Res. pmid:690514
Bhattacharyya AK and Eggen DA Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol. 1981 J. Lipid Res. pmid:7217781
Lindenthal B et al. Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. 2001 J. Lipid Res. pmid:11441136
Sheu JH et al. Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata. 1996 J. Nat. Prod. pmid:8984148
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. 1979 J. Natl. Cancer Inst. pmid:384010
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Dennick RG et al. Desmosterol levels in human foetal brain--a reassessment. 1973 J. Neurochem. pmid:4697890
Dennick RG et al. Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. 1974 J. Neurochem. pmid:4854410
Levi O et al. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. 2005 J. Neurochem. pmid:16190879
Bourre JM et al. Precursors for cholesterol synthesis (7-dehydrocholesterol, 7-dehydrodesmosterol, and desmosterol): cholesterol/7-dehydrocholesterol ratio as an index of development and aging in PNS but not in CNS. 1990 J. Neurochem. pmid:2156015
Kim JH et al. Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. 2010 J. Neurochem. pmid:19860851
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Jurevics H and Morell P Cholesterol for synthesis of myelin is made locally, not imported into brain. 1995 J. Neurochem. pmid:7830084
Heacock AM et al. Cholesterol synthesis and nerve regeneration. 1984 J. Neurochem. pmid:6699648
Fumagalli R and Paoletti P Radioimmunoassay of glioma associated antigen in CSF and its usefulness for the diagnosis and monitoring of human glioma. 1991 J. Neurooncol. pmid:1919650
Bernini F et al. Selected ion monitoring technique for the evaluation of sterols in cerebrospinal fluid: a new approach to desmosterol test for central nervous system tumors. 1986 J. Neurooncol. pmid:3746383