DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

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Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Lütjohann D et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. 2002 J. Lipid Res. pmid:12091492
Murphy KJ et al. Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis). 2002 Lipids pmid:12120958
Lindenthal B et al. Influence of simvastatin, pravastatin, and BM 15.766 on neutral sterols in liver and testis of guinea pigs. 2002 Metab. Clin. Exp. pmid:11912560
Chevy F et al. Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. 2002 J. Lipid Res. pmid:12177163
Fernández C et al. Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. 2002 Biochem. J. pmid:12162789
Berge KE et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. 2002 J. Lipid Res. pmid:11893785
Simonen P et al. Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes. 2002 Clin. Chim. Acta pmid:11750274
Hallikainen M et al. Short-term LDL cholesterol-lowering efficacy of plant stanol esters. 2002 BMC Cardiovasc Disord pmid:12197945
Khripach VA et al. [Synthesis of C24-functionalized hydroxysterols]. 2002 May-Jun Bioorg. Khim. pmid:12077856
Cross NL Decrease in order of human sperm lipids during capacitation. 2003 Biol. Reprod. pmid:12700200
Westover EJ and Covey DF First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. 2003 Steroids pmid:12606007
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Juvet LK et al. On the role of liver X receptors in lipid accumulation in adipocytes. 2003 Mol. Endocrinol. pmid:12554745
Johnston JJ et al. Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. 2003 J. Agric. Food Chem. pmid:12502398
Okumura K et al. Formal synthesis of squalamine from desmosterol. 2003 Chem. Pharm. Bull. pmid:14519925
Miettinen TA and Gylling H Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. 2003 Eur. J. Clin. Invest. pmid:14636301
Pikuleva I and Javitt NB Novel sterols synthesized via the CYP27A1 metabolic pathway. 2003 Arch. Biochem. Biophys. pmid:14622972
Otte K et al. Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. 2003 Mol. Cell. Biol. pmid:12529392
Wechsler A et al. Generation of viable cholesterol-free mice. 2003 Science pmid:14684813
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643
Matthan NR et al. Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL. 2003 J. Lipid Res. pmid:12562840
Teunissen CE et al. Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. 2003 Jan-Feb Neurobiol. Aging pmid:12493560
Sánchez-Machado DI et al. An HPLC method for the quantification of sterols in edible seaweeds. 2004 Biomed. Chromatogr. pmid:15103705
Mutka AL et al. Secretion of sterols and the NPC2 protein from primary astrocytes. 2004 J. Biol. Chem. pmid:15355983
Yu H et al. Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. 2004 BMC Dev. Biol. pmid:15005800
Javitt NB Oxysteroids: a new class of steroids with autocrine and paracrine functions. 2004 Trends Endocrinol. Metab. pmid:15380811
Miller RR et al. Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success. 2004 Cryobiology pmid:15351685
Choi HS and Kim YW [Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells]. 2004 Korean J Gastroenterol pmid:15665577
Pihlajamäki J et al. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. 2004 J. Lipid Res. pmid:14657199
Luciani P et al. Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. 2004 J. Clin. Endocrinol. Metab. pmid:15001630
Sanocka D and Kurpisz M Reactive oxygen species and sperm cells. 2004 Reprod. Biol. Endocrinol. pmid:15038829
Yoder CA et al. Effectiveness of twenty, twenty-five diazacholesterol, avian gonadotropin-releasing hormone, and chicken riboflavin carrier protein for inhibiting reproduction in Coturnix quail. 2004 Poult. Sci. pmid:14979575
Gylling H et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. 2004 J. Lipid Res. pmid:15175352
Martin-Creuzburg D and Von Elert E Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. 2004 J. Chem. Ecol. pmid:15139303
Beasley CL et al. Reductions in cholesterol and synaptic markers in association cortex in mood disorders. 2005 Bipolar Disord pmid:16176438
Miller RR et al. Comparative aspects of sperm membrane fatty acid composition in silver (Vulpes vulpes) and blue (Alopex lagopus) foxes, and their relationship to cell cryopreservation. 2005 Cryobiology pmid:16040024
Phleger CF et al. Lipid composition of deep-sea hydrothermal vent tubeworm Riftia pachyptila, crabs Munidopsis subsquamosa and Bythograea thermydron, mussels Bathymodiolus sp. and limpets Lepetodrilus spp. 2005 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:15893489
Domeño C et al. Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. 2005 Anal Bioanal Chem pmid:15827725
Chevy F et al. Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit. 2005 Prenat. Diagn. pmid:16231320
Scheidt HA et al. Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. 2005 Biophys. J. pmid:16085761
Yu H and Patel SB Recent insights into the Smith-Lemli-Opitz syndrome. 2005 Clin. Genet. pmid:16207203
Levi O et al. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. 2005 J. Neurochem. pmid:16190879
Berring EE et al. A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study. 2005 Chem. Phys. Lipids pmid:15904906
Huster D et al. Desmosterol may replace cholesterol in lipid membranes. 2005 Biophys. J. pmid:15596512
Liu Y et al. Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. 2005 Mol. Endocrinol. pmid:15761033
Nagy K et al. Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics. 2006 Rapid Commun. Mass Spectrom. pmid:16841361
Benvenuti S et al. Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. 2006 Exp. Cell Res. pmid:16762343
Hallikainen M et al. Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters. 2006 Atherosclerosis pmid:16386259
Siirtola A et al. Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. 2006 Transplantation pmid:16477216
Megha O et al. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. 2006 J. Biol. Chem. pmid:16735517
Hallikainen M et al. Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption. 2006 Clin. Chim. Acta pmid:16814761
Wang JH and Tuohimaa P Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells. 2006 Biochem. Biophys. Res. Commun. pmid:16696936
Lee CS et al. Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. 2006 Neuroreport pmid:16407768
Yang C et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. 2006 J. Biol. Chem. pmid:16857673
Mirza R et al. DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis. 2006 J. Invest. Dermatol. pmid:16410790
Ahmida HS et al. Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16807145
Ohyama Y et al. Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. 2006 J. Biol. Chem. pmid:16321981
Vainio S et al. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. 2006 J. Biol. Chem. pmid:16249181
Hedman M et al. Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. 2006 J. Pediatr. pmid:16492436
Lu X et al. DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. 2006 Endocrinology pmid:16513830
Stottrup BL and Keller SL Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. 2006 Biophys. J. pmid:16461392
Mazalli MR et al. HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. 2006 Lipids pmid:16981439
Hallikainen M et al. Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome. 2006 Am. J. Clin. Nutr. pmid:17158421
Gylling H et al. Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease. 2006 Mar-Apr Menopause pmid:16645542
Souchet N and Laplante S Seasonal and geographical variations of sterol composition in snow crab hepatopancreas and pelagic fish viscera from Eastern Quebec. 2007 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:17374564
Samuli Ollila OH et al. Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. 2007 J. Struct. Biol. pmid:17369050
Simonen PP et al. The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. 2007 Atherosclerosis pmid:16963050
Hallikainen M et al. Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. 2007 Clin. Chim. Acta pmid:17573060
Cubells L et al. Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex. 2007 Traffic pmid:17822395
Zhang S et al. Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. 2007 Appl. Environ. Microbiol. pmid:17220261
Stojakovic T et al. Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid. 2007 Hepatology pmid:17668874
Heverin M et al. Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17761942
Solcà C et al. Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. 2007 Mol. Genet. Metab. pmid:17197219
Yu H et al. Quantifying raft proteins in neonatal mouse brain by 'tube-gel' protein digestion label-free shotgun proteomics. 2007 Proteome Sci pmid:17892558
Niemelä PS et al. Assessing the nature of lipid raft membranes. 2007 PLoS Comput. Biol. pmid:17319738
Lu B et al. Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. 2007 Anal. Chim. Acta pmid:17386793
Mirza R et al. Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. 2008 Br. J. Dermatol. pmid:18241265
Tedde A et al. Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. 2008 Am. J. Med. Genet. B Neuropsychiatr. Genet. pmid:17579359
Luciani P et al. Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. 2008 Endocrinology pmid:18499757
Kervizic G and Corcos L Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. 2008 BMC Syst Biol pmid:19025648
de Sain-van der Velden MG et al. Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. 2008 J. Inherit. Metab. Dis. pmid:18949577
Rodríguez-Acebes S et al. Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. 2008 Biochem. Biophys. Res. Commun. pmid:18851952
Pasanen MK et al. Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate. 2008 Pharmacogenet. Genomics pmid:18794729
Peri A and Serio M Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1. 2008 Neuropsychiatr Dis Treat pmid:19043524
Legg RL et al. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. 2008 Reprod. Biol. Endocrinol. pmid:19025659
Griffiths WJ et al. Discovering oxysterols in plasma: a window on the metabolome. 2008 J. Proteome Res. pmid:18605750
Jansen M et al. Cholesterol substitution increases the structural heterogeneity of caveolae. 2008 J. Biol. Chem. pmid:18353778
Fassbender K et al. Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. 2008 Atherosclerosis pmid:17137582
Róg T et al. Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. 2008 J Chem Phys pmid:19045210
Berthold HK et al. SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment. 2008 Exp. Clin. Endocrinol. Diabetes pmid:18072016
Burgess B et al. Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18599800
Assmann G et al. Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia. 2008 Curr Med Res Opin pmid:18053317
Shrivastava S et al. Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization. 2008 Biochemistry pmid:18442257
Wang N et al. ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. 2008 FASEB J. pmid:18039927
Pedretti A et al. Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. 2008 Steroids pmid:18394665
Shay CM et al. Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. 2009 J Diabetes pmid:20827426
Drzewińska J et al. [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. 2009 Postepy Hig Med Dosw (Online) pmid:19597241
Matiz C et al. Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? 2009 Pediatr Rheumatol Online J pmid:19814780
Kuehnle K Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). 2009 Neurochem. Res. pmid:19475506
Singh P et al. Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis. 2009 Biochim. Biophys. Acta pmid:19616511