DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Haldar S et al. Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. 2012 Biophys. J. pmid:22500756
Weeks AC et al. Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin. 2012 Curr. Eye Res. pmid:22050601
Feio CA et al. Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis. 2012 J. Atheroscler. Thromb. pmid:22139433
Tansley G et al. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. 2012 Curr Gerontol Geriatr Res pmid:22649448
Zerenturk EJ et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). 2012 Biochim. Biophys. Acta pmid:22178193
Meljon A et al. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. 2012 J. Lipid Res. pmid:22891291
Bieghs V et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. 2012 PLoS ONE pmid:22470565
Kasmas SH et al. Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies. 2012 Braz. J. Med. Biol. Res. pmid:22801416
McDonald JG et al. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. 2012 J. Lipid Res. pmid:22517925
Cacabelos R et al. Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. 2012 Int J Alzheimers Dis pmid:22482072
Khanavi M et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. 2012 Pharmacogn Mag pmid:22438665
Swaminathan S et al. Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. 2012 Brain Imaging Behav pmid:21901424
Sato Y et al. Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. 2012 J. Lipid Res. pmid:22203775
Rodgers MA et al. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. 2012 J. Am. Chem. Soc. pmid:22480142
Silbernagel G et al. Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. 2012 Exp Diabetes Res pmid:22203835
Bogan RL et al. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. 2012 Biol. Reprod. pmid:22156476
Spann NJ et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. 2012 Cell pmid:23021221
Min HK et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. 2012 Cell Metab. pmid:22560219
Matysik S et al. Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. 2012 Clin. Chem. pmid:22997279
Lim L et al. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. 2012 Cell Death Differ. pmid:21818119