DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Legault Y et al. The binding of sterol sulfates to hamster spermatozoa. 1979 Steroids pmid:483338
James MJ and Kandutsch AA Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures. 1979 J. Biol. Chem. pmid:468837
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. 1979 J. Natl. Cancer Inst. pmid:384010
Francisco C et al. Side chain-hydroxylated sterols of the red alga Asparagopsis armata: significant products or artifacts due to autoxidation? 1979 Steroids pmid:494359
Ortiz de Montellano PR et al. Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. 1979 Biochem. Biophys. Res. Commun. pmid:508352
Burck PJ and Zimmerman RE The inhibition of acrosin by sterol sulphates. 1980 J. Reprod. Fertil. pmid:6987395
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Paoletti P Desmosterol in CSF. 1981 Neurology pmid:7194986
Kwieciński H Myotonia induced by chemical agents. 1981 Crit. Rev. Toxicol. pmid:7026172
Nes WR et al. Steric effects at C-20 and C-24 on the metabolism of sterols by Tetrahymena pyriformis. 1981 J. Lipid Res. pmid:6793681
Huijmans JG et al. Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. 1981 Acta Endocrinol. pmid:6263029
Sekula BC and Nes WR Metabolism of sterols by anaerobic Saccharomyces cerevisiae. 1981 Lipids pmid:7012521
Albers-Schönberg G et al. Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. 1981 J. Antibiot. pmid:7275832
Bhattacharyya AK and Eggen DA Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol. 1981 J. Lipid Res. pmid:7217781
Wasserstrom WR et al. Cerebrospinal fluid biochemical markers in central nervous system tumors: a review. 1981 May-Jun Ann. Clin. Lab. Sci. pmid:6166240
Chalikian DM and Barchi RL Sarcolemmal desmosterol accumulation and membrane physical properties in 20,25-diazacholesterol myotonia. 1982 Muscle Nerve pmid:7070392
Sarkar CP et al. Studies on the mechanisms of the epileptiform activity induced by U186661. I Gross alteration of the lipids of synaptosomes and myelin. 1982 Epilepsia pmid:7084136
D'Alonzo AJ and McArdle JJ An evaluation of fast- and slow-twitch muscle from rats treated with 20,25-diazacholesterol. 1982 Exp. Neurol. pmid:7117485
Svoboda JA et al. Utilization and metabolism of dietary sterols in the honey bee and the yellow fever mosquito. 1982 Lipids pmid:7087696
Kling D and Gamble W Cholesterol biosynthesis in polychlorinated biphenyl-treated rats. 1982 Environ. Res. pmid:6802634
Sarkar CP and Cenedella RJ Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. 1982 Lipids pmid:6177997
Clark RM et al. Desmosterol in human milk. 1983 Lipids pmid:6855485
Pullinger CR and Gibbons GF The relationship between the rate of hepatic sterol synthesis and the incorporation of [3H]water. 1983 J. Lipid Res. pmid:6644182
Chitwood DJ et al. Novel nuclear methylation of sterols by the nematode Caenorhabditis elegans. 1983 Steroids pmid:6673193
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Bouthillier M et al. Distribution of steroid sulfotransferase in the male hamster reproductive tract. 1984 Biol. Reprod. pmid:6240284
Hietter H et al. Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells. 1984 Biochem. Biophys. Res. Commun. pmid:6732777
Ashraf J et al. Membrane fluidity and myotonia: effects of cholesterol and desmosterol on erythrocyte membrane fluidity in rats with 20,25-diazacholesterol-induced myotonia and on phospholipid liposomes. 1984 Biosci. Rep. pmid:6713083
Leonard DA and Chen HW Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. 1984 J. Biol. Chem. pmid:6425279
Patel DD et al. The absolute rate of cholesterol biosynthesis in monocyte-macrophages from normal and familial hypercholesterolaemic subjects. 1984 Biochem. J. pmid:6743229
Clejan S and Bittman R Distribution and movement of sterols with different side chain structures between the two leaflets of the membrane bilayer of mycoplasma cells. 1984 J. Biol. Chem. pmid:6706946
Heacock AM et al. Cholesterol synthesis and nerve regeneration. 1984 J. Neurochem. pmid:6699648
Schroeder F et al. Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. 1984 Biochem. Biophys. Res. Commun. pmid:6497882
Jeng I et al. Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. 1985 Biochem. Pharmacol. pmid:3994747
Jaeckle KA Assessment of tumor markers in cerebrospinal fluid. 1985 Clin. Lab. Med. pmid:2411459
Bouthillier M et al. The assay and partial characterization of 3 beta-hydroxysteroid sulfotransferase of the hamster epididymis. 1985 Can. J. Biochem. Cell Biol. pmid:3157430
Pentchev PG et al. The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. 1986 J. Biol. Chem. pmid:3949747
Bernini F et al. Selected ion monitoring technique for the evaluation of sterols in cerebrospinal fluid: a new approach to desmosterol test for central nervous system tumors. 1986 J. Neurooncol. pmid:3746383
Chen JK et al. Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. 1986 Exp. Cell Res. pmid:3943557
Vuoristo M and Miettinen TA Serum cholesterol precursor sterols in coeliac disease: effects of gluten free diet and cholestyramine. 1986 Gut pmid:3792914
Bhattacharyya AK and Eggen DA Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys. 1987 Atherosclerosis pmid:3675704
Slotte JP and Bierman EL Movement of plasma-membrane sterols to the endoplasmic reticulum in cultured cells. 1987 Biochem. J. pmid:3435441
Björkhem I et al. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. 1987 J. Lipid Res. pmid:3681138
Roberts KD Sterol sulfates in the epididymis; synthesis and possible function in the reproductive process. 1987 J. Steroid Biochem. pmid:3480393
Neuvonen PJ et al. The mechanism of the hypocholesterolaemic effect of activated charcoal. 1989 Eur. J. Clin. Invest. pmid:2509211
Goh EH et al. HPLC analysis of desmosterol, 7-dehydrocholesterol, and cholesterol. 1989 Lipids pmid:2779370
Bourre JM et al. Alterations of cholesterol synthesis precursors (7-dehydrocholesterol, 7-dehydrodesmosterol, desmosterol) in dysmyelinating neurological mutant mouse (quaking, shiverer and trembler) in the PNS and the CNS. 1989 Biochim. Biophys. Acta pmid:2547434
Awano M et al. Identification of cholesta-7,24-dien-3 beta-ol and desmosterol in hamster cauda epididymal spermatozoa. 1989 Lipids pmid:2779373
Tabas I et al. The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction. 1989 J. Clin. Invest. pmid:2592557