DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Kölsch H et al. Alterations of cholesterol precursor levels in Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20226877
Martinez-Seara H et al. Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes. 2010 PLoS ONE pmid:20567600
Pihlajamäki J et al. Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding. 2010 Metab. Clin. Exp. pmid:20015521
Jiménez-López JM et al. Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. 2010 Lipids Health Dis pmid:20338039
Pakarinen MP et al. Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition. 2010 Dig Liver Dis pmid:20538532
Schmelzer C et al. The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. 2010 IUBMB Life pmid:21086475
Hoenig MR and Sellke FW Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy. 2010 Atherosclerosis pmid:20356594
Vanmierlo T et al. Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. 2010 J. Alzheimers Dis. pmid:20061631
Zalata A et al. Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient. 2010 Int. J. Androl. pmid:19490187
Mourvaki E et al. Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility. 2010 Asian J. Androl. pmid:20729867
Gallego O et al. A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. 2010 Mol. Syst. Biol. pmid:21119626
Moraes EA et al. Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. 2010 Anim. Reprod. Sci. pmid:19733986
Strandberg TE et al. Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. 2010 Atherosclerosis pmid:19962145
Serra M et al. Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. 2010 J. Steroid Biochem. Mol. Biol. pmid:20804844
Chau PL New insights into the molecular mechanisms of general anaesthetics. 2010 Br. J. Pharmacol. pmid:20735416
Caesar R et al. A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences. 2010 PLoS ONE pmid:20634946
Martijn C and Wiklund L Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain. 2010 BMC Med Genomics pmid:20594294
Andreyev AY et al. Subcellular organelle lipidomics in TLR-4-activated macrophages. 2010 J. Lipid Res. pmid:20574076
Wei D et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. 2010 Diabetes pmid:19933995
Endo A A historical perspective on the discovery of statins. 2010 Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. pmid:20467214
Nissinen MJ et al. Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men. 2010 Nutr Metab Cardiovasc Dis pmid:19695854
Daniels TF et al. The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle. 2010 PLoS ONE pmid:21151936
Fon Tacer K et al. Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. 2010 J. Steroid Biochem. Mol. Biol. pmid:20206258
Buffone MG et al. High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. 2009 Sep-Oct J. Androl. pmid:19269935
Matthan NR et al. Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. 2009 J. Lipid Res. pmid:19436064
Miettinen TA et al. Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study. 2009 Nutr Metab Cardiovasc Dis pmid:19185477
Mirza R et al. Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice. 2009 Am J Dermatopathol pmid:19542918
Shay CM et al. Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. 2009 J Diabetes pmid:20827426
Laitinen K et al. Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. 2009 Br. J. Nutr. pmid:19017423
Drzewińska J et al. [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. 2009 Postepy Hig Med Dosw (Online) pmid:19597241
Peri A et al. New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. 2009 Front Neuroendocrinol pmid:19351544
Rodríguez-Acebes S et al. Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. 2009 Biochem. J. pmid:19260826
Matiz C et al. Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? 2009 Pediatr Rheumatol Online J pmid:19814780
Kuehnle K Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). 2009 Neurochem. Res. pmid:19475506
Singh P et al. Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis. 2009 Biochim. Biophys. Acta pmid:19616511
Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Stevenson J and Brown AJ How essential is cholesterol? 2009 Biochem. J. pmid:19426142
Kuehnle K et al. Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. 2009 Neurochem. Res. pmid:19115107
Mirza R et al. Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. 2008 Br. J. Dermatol. pmid:18241265
Luciani P et al. Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. 2008 Endocrinology pmid:18499757
de Sain-van der Velden MG et al. Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. 2008 J. Inherit. Metab. Dis. pmid:18949577
Rodríguez-Acebes S et al. Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. 2008 Biochem. Biophys. Res. Commun. pmid:18851952
Pasanen MK et al. Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate. 2008 Pharmacogenet. Genomics pmid:18794729
Peri A and Serio M Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1. 2008 Neuropsychiatr Dis Treat pmid:19043524
Róg T et al. Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. 2008 J Chem Phys pmid:19045210
Berthold HK et al. SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment. 2008 Exp. Clin. Endocrinol. Diabetes pmid:18072016
Assmann G et al. Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia. 2008 Curr Med Res Opin pmid:18053317
Shrivastava S et al. Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization. 2008 Biochemistry pmid:18442257
Wang N et al. ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. 2008 FASEB J. pmid:18039927
Pedretti A et al. Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. 2008 Steroids pmid:18394665