DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
HERNDON JH and SIPERSTEIN MD Desmosterol deposition in human and experimental atherosclerosis. 1963 Circ. Res. pmid:13953991
WHITBY LG et al. THE ESTIMATION OF DESMOSTEROL AND CHOLESTEROL IN PLASMA. 1964 Br Heart J pmid:14132032
POTTIER J and BUSIGNY M [DETERMINATION OF DESMOSTEROL IN SERUM]. 1964 Clin. Chim. Acta pmid:14231926
CHOBANIAN AV and HOLLANDER W TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY. 1965 J. Lipid Res. pmid:14280470
SACHS BA and WOLFMAN L Studies of serum desmosterol levels in hypercholesteremic subjects treated with triparanol (MER-29). 1961 Nov-Dec Am. J. Clin. Nutr. pmid:14495832
Okumura K et al. Formal synthesis of squalamine from desmosterol. 2003 Chem. Pharm. Bull. pmid:14519925
Svoboda JA and Thompson MJ Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations. 1967 J. Lipid Res. pmid:14564725
Pikuleva I and Javitt NB Novel sterols synthesized via the CYP27A1 metabolic pathway. 2003 Arch. Biochem. Biophys. pmid:14622972
Miettinen TA and Gylling H Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. 2003 Eur. J. Clin. Invest. pmid:14636301
Pihlajamäki J et al. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. 2004 J. Lipid Res. pmid:14657199
Wechsler A et al. Generation of viable cholesterol-free mice. 2003 Science pmid:14684813
Yoder CA et al. Effectiveness of twenty, twenty-five diazacholesterol, avian gonadotropin-releasing hormone, and chicken riboflavin carrier protein for inhibiting reproduction in Coturnix quail. 2004 Poult. Sci. pmid:14979575
Luciani P et al. Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. 2004 J. Clin. Endocrinol. Metab. pmid:15001630
Yu H et al. Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. 2004 BMC Dev. Biol. pmid:15005800
Sanocka D and Kurpisz M Reactive oxygen species and sperm cells. 2004 Reprod. Biol. Endocrinol. pmid:15038829
Sánchez-Machado DI et al. An HPLC method for the quantification of sterols in edible seaweeds. 2004 Biomed. Chromatogr. pmid:15103705
Martin-Creuzburg D and Von Elert E Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. 2004 J. Chem. Ecol. pmid:15139303
Gylling H et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. 2004 J. Lipid Res. pmid:15175352
Miller RR et al. Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success. 2004 Cryobiology pmid:15351685
Mutka AL et al. Secretion of sterols and the NPC2 protein from primary astrocytes. 2004 J. Biol. Chem. pmid:15355983