DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Awata N et al. Carbon-carbon bond cleavage of fucosterol-24, 28-oxide by cell-free extracts of silkworm Bombyx mori. 1975 Biochem. Biophys. Res. Commun. pmid:167728
Seiler D et al. [Effect of sterol composition on the activity of transport-ATPase of the erythrocyte membrane]. 1975 Verh Dtsch Ges Inn Med pmid:132802
Nagatomo T and Peter JB (Na+ + K+)-ATPase activity in rats with 20, 25-diazacholesterol-induced myotonia. 1975 Exp. Neurol. pmid:123512
Svoboda JA et al. Recent developments in insect steroid metabolism. 1975 Annu. Rev. Entomol. pmid:1091201
Chen SM et al. Letter: Stereospecificity in the conversion of fucosterol 24,28-epoxide to desmosterol in the silkworm, Bombyx mori. 1975 J. Am. Chem. Soc. pmid:1165366
Turi JS et al. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells IV: Uptake and release kinetics of sterols. 1975 J Pharm Sci pmid:1170314
Bleau G et al. Desmosteryl sulphate of hamster spermatozoa, a potent inhibitor of capacitation in vitro. 1975 J. Reprod. Fertil. pmid:1127634
Fujimoto Y et al. Studies on steroids. Part XXIX. Synthesis of allenic analogues fucosterol and desmosterol. 1975 J. Chem. Soc. Perkin Trans. I pmid:1239449
Kuksis A et al. Identification of plant sterols in plasma and red blood cells of man and experimental animals. 1976 Lipids pmid:972575
Lalumière G et al. Cholesteryl sulfate and sterol sulfatase in the human reproductive tract. 1976 Steroids pmid:1273889
Pleasure D and Kim SU Sterol synthesis by myelinating cultures of mouse spinal cord. 1976 Brain Res. pmid:175882
Weiss JF et al. Desmosterol in human and experimental brain tumors in tissue culture. 1976 Arch. Neurol. pmid:1252160
Bagshawe KD and Harland S Detection of intracranial tumours with special reference to immunodiagnosis. 1976 Proc. R. Soc. Med. pmid:945577
Arthur JR et al. Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue. 1976 Biochem. J. pmid:986816
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Svoboda JA et al. Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines. 1977 Lipids pmid:909356
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Abernethy DR and Azarnoff DL Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. 1977 Biochem. Pharmacol. pmid:849344
Ochi K et al. Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. 1977 Steroids pmid:611642