DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Svoboda JA et al. Intermediates of stigmasterol metabolism in Spodoptera littoralis. 1989 Mar-May Steroids pmid:2799849
Goh EH et al. Analysis of cholesterol and desmosterol in cultured cells without organic solvent extraction. 1990 Lipids pmid:2280678
Bourre JM et al. Precursors for cholesterol synthesis (7-dehydrocholesterol, 7-dehydrodesmosterol, and desmosterol): cholesterol/7-dehydrocholesterol ratio as an index of development and aging in PNS but not in CNS. 1990 J. Neurochem. pmid:2156015
Saucier SE et al. Oxygenation of desmosterol and cholesterol in cell cultures. 1990 J. Lipid Res. pmid:2090711
Dai MC et al. Phospholipid studies of marine organisms: 26. Interactions of some marine sterols with 1-stearoyl-2-oleoyl phosphatidylcholine (SOPC) in model membranes. 1991 Chem. Phys. Lipids pmid:1804568
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Fumagalli R and Paoletti P Radioimmunoassay of glioma associated antigen in CSF and its usefulness for the diagnosis and monitoring of human glioma. 1991 J. Neurooncol. pmid:1919650
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Yagi T et al. Stereochemistry of hydrogen addition to C-25 of desmosterol by sterol-delta 24-reductase of rat liver homogenate. 1994 Chem. Pharm. Bull. pmid:8004717
Zeeck E et al. Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea. 1994 Steroids pmid:8073448
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Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Jurevics H and Morell P Cholesterol for synthesis of myelin is made locally, not imported into brain. 1995 J. Neurochem. pmid:7830084
Sheu JH et al. Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata. 1996 J. Nat. Prod. pmid:8984148
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Fliesler SJ et al. Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition. 2000 Lipids pmid:10783006
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Fujimoto Y et al. [Studies on the biosynthesis of sterol side chain in higher plants]. 2000 Yakugaku Zasshi pmid:11082699
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Waterham HR et al. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. 2001 Am. J. Hum. Genet. pmid:11519011
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Sion B et al. Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography. 2001 J Chromatogr A pmid:11762778
Tammi A et al. Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. 2001 J. Nutr. pmid:11435511
Phleger CF et al. Interannual variations in the lipids of the Antarctic pteropods Clione limacina and Clio pyramidata. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11250551
Serfis AB et al. Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films. 2001 Biochim. Biophys. Acta pmid:11286977
Lindenthal B et al. Progestins block cholesterol synthesis to produce meiosis-activating sterols. 2001 FASEB J. pmid:11259396
Lindenthal B et al. Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. 2001 J. Lipid Res. pmid:11441136
Phleger CF et al. Interannual and between species comparison of the lipids, fatty acids and sterols of Antarctic krill from the US AMLR Elephant Island survey area. 2002 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11923086
Vaskonen T et al. Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet. 2002 Br. J. Nutr. pmid:12064332
Moghadasian MH et al. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. 2002 J. Clin. Pathol. pmid:12401826
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Andersson HC et al. Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. 2002 Am. J. Med. Genet. pmid:12457401
Sudhop T et al. Serum plant sterols as a potential risk factor for coronary heart disease. 2002 Metab. Clin. Exp. pmid:12489060