DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Svoboda JA et al. | Utilization and metabolism of dietary sterols in the honey bee and the yellow fever mosquito. | 1982 | Lipids | pmid:7087696 |
| D'Alonzo AJ and McArdle JJ | An evaluation of fast- and slow-twitch muscle from rats treated with 20,25-diazacholesterol. | 1982 | Exp. Neurol. | pmid:7117485 |
| Long TT et al. | The sources of rat biliary cholesterol and bile acid. | 1978 | J. Lipid Res. | pmid:712246 |
| Paoletti P | Desmosterol in CSF. | 1981 | Neurology | pmid:7194986 |
| Evans RW and Tinoco J | Monolayers of sterols and phosphatidylcholines containing a 20-carbon chain. | 1978 | Chem. Phys. Lipids | pmid:719817 |
| Bhattacharyya AK and Eggen DA | Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol. | 1981 | J. Lipid Res. | pmid:7217781 |
| Ramsey RB | Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. | 1977 | Lipids | pmid:72342 |
| Albers-Schönberg G et al. | Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. | 1981 | J. Antibiot. | pmid:7275832 |
| Doi O and Endo A | Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. | 1978 | Jpn. J. Med. Sci. Biol. | pmid:732030 |
| Legault Y et al. | 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. | 1978 | Steroids | pmid:734699 |