DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
HÄ…c-Wydro K et al. The influence of cholesterol precursor--desmosterol--on artificial lipid membranes. 2015 Biochim. Biophys. Acta pmid:25960185
Sokoloff L and Rothblat GH Regulation of sterol synthesis in L cells: steady-state and transitional responses. 1972 Biochim. Biophys. Acta pmid:5070653
Zerenturk EJ et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). 2012 Biochim. Biophys. Acta pmid:22178193
Bojesen I and Roepstorff P Identification of C sterols produced by rat renal inner medulla in vitro. 1973 Biochim. Biophys. Acta pmid:4722467
Serfis AB et al. Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films. 2001 Biochim. Biophys. Acta pmid:11286977
Collignon-Thiennot F et al. [Demonstration of 2 pathways for cholesterol synthesis in the mollusk: patella Patella vulgata L., (Gasteropoda, Prosobranches, Archeogasteropoda)]. 1973 Biochimie pmid:4754188
Bouthillier M et al. Distribution of steroid sulfotransferase in the male hamster reproductive tract. 1984 Biol. Reprod. pmid:6240284
Cross NL Decrease in order of human sperm lipids during capacitation. 2003 Biol. Reprod. pmid:12700200
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Bogan RL et al. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. 2012 Biol. Reprod. pmid:22156476
Boerke A et al. Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization. 2013 Biol. Reprod. pmid:23115269
Sánchez-Machado DI et al. An HPLC method for the quantification of sterols in edible seaweeds. 2004 Biomed. Chromatogr. pmid:15103705
Khripach VA et al. [Synthesis of C24-functionalized hydroxysterols]. 2002 May-Jun Bioorg. Khim. pmid:12077856
Saini R et al. Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. 2013 Bioorg. Med. Chem. pmid:23910990
Fujimoto Y et al. Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa. 1998 Bioorg. Med. Chem. Lett. pmid:9871655
Haldar S et al. Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. 2012 Biophys. J. pmid:22500756
Scheidt HA et al. Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. 2005 Biophys. J. pmid:16085761
Huster D et al. Desmosterol may replace cholesterol in lipid membranes. 2005 Biophys. J. pmid:15596512
Stottrup BL and Keller SL Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. 2006 Biophys. J. pmid:16461392
Nagata S and Nagasawa H Sterol composition in larvae of the silkworm, Bombyx mori. 2011 Biosci. Biotechnol. Biochem. pmid:21597175