DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Javitt NB Oxysteroids: a new class of steroids with autocrine and paracrine functions. 2004 Trends Endocrinol. Metab. pmid:15380811
Huster D et al. Desmosterol may replace cholesterol in lipid membranes. 2005 Biophys. J. pmid:15596512
Choi HS and Kim YW [Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells]. 2004 Korean J Gastroenterol pmid:15665577
Liu Y et al. Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. 2005 Mol. Endocrinol. pmid:15761033
Domeño C et al. Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. 2005 Anal Bioanal Chem pmid:15827725
Phleger CF et al. Lipid composition of deep-sea hydrothermal vent tubeworm Riftia pachyptila, crabs Munidopsis subsquamosa and Bythograea thermydron, mussels Bathymodiolus sp. and limpets Lepetodrilus spp. 2005 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:15893489
Berring EE et al. A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study. 2005 Chem. Phys. Lipids pmid:15904906
Miller RR et al. Comparative aspects of sperm membrane fatty acid composition in silver (Vulpes vulpes) and blue (Alopex lagopus) foxes, and their relationship to cell cryopreservation. 2005 Cryobiology pmid:16040024
Scheidt HA et al. Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. 2005 Biophys. J. pmid:16085761
Beasley CL et al. Reductions in cholesterol and synaptic markers in association cortex in mood disorders. 2005 Bipolar Disord pmid:16176438
Levi O et al. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. 2005 J. Neurochem. pmid:16190879
Yu H and Patel SB Recent insights into the Smith-Lemli-Opitz syndrome. 2005 Clin. Genet. pmid:16207203
Chevy F et al. Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit. 2005 Prenat. Diagn. pmid:16231320
Vainio S et al. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. 2006 J. Biol. Chem. pmid:16249181
Ohyama Y et al. Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. 2006 J. Biol. Chem. pmid:16321981
Kojima H et al. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. 1992 Biochem. Biophys. Res. Commun. pmid:1632778
Hallikainen M et al. Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters. 2006 Atherosclerosis pmid:16386259
Lee CS et al. Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. 2006 Neuroreport pmid:16407768
Mirza R et al. DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis. 2006 J. Invest. Dermatol. pmid:16410790
Stottrup BL and Keller SL Phase behavior of lipid monolayers containing DPPC and cholesterol analogs. 2006 Biophys. J. pmid:16461392