DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Gibbons GF and Pullinger CR Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. 1977 Biochem. J. pmid:849287
Ramsey RB Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. 1977 Lipids pmid:72342
Palamarchuk VI and Koval' VG [Isolation and identification of desmosterol and its concentration in animal brain tissue]. 1977 Mar-Apr Ukr Biokhim Zh pmid:867530
Legault Y et al. 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. 1978 Steroids pmid:734699
Pettler PJ et al. Mechanism of dealkylation of clionasterol in the insect Tenebrio molitor. 1978 Biochem. J. pmid:708391
Long TT et al. The sources of rat biliary cholesterol and bile acid. 1978 J. Lipid Res. pmid:712246
Gibbons GF and Pullinger CR Cholesterol biosynthesis in hepatocytes. 1978 Biochem. Soc. Trans. pmid:744335
Bierkamper GG and Cenedella RJ Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A. 1978 Brain Res. pmid:678974
Albers HK et al. [The problem of characterization of sterins in the gingiva by means of gas chromatography--mass spectrometry]. 1978 Dtsch Zahnarztl Z pmid:280451
Volpe JJ et al. Regulation of cholesterol ester synthesis in cultured glial and neuronal cells. Relation to control of cholesterol synthesis. 1978 Biochim. Biophys. Acta pmid:205252
Chau IY and Geyer RP The effects of serum albumin and phospholipid on sterol excretion in tissue culture cells. 1978 Biochim. Biophys. Acta pmid:687659
Evans RW and Tinoco J Monolayers of sterols and phosphatidylcholines containing a 20-carbon chain. 1978 Chem. Phys. Lipids pmid:719817
Doi O and Endo A Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. 1978 Jpn. J. Med. Sci. Biol. pmid:732030
Hansbury E and Scallen TJ Resolution of desmosterol, cholesterol, and other sterol intermediates by reverse-phase high-pressure liquid chromatography. 1978 J. Lipid Res. pmid:690514
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors in cerebrospinal fluid. 1978 Nov-Dec Ann. Clin. Lab. Sci. pmid:736510
Legault Y et al. The binding of sterol sulfates to hamster spermatozoa. 1979 Steroids pmid:483338
James MJ and Kandutsch AA Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures. 1979 J. Biol. Chem. pmid:468837
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. 1979 J. Natl. Cancer Inst. pmid:384010
Francisco C et al. Side chain-hydroxylated sterols of the red alga Asparagopsis armata: significant products or artifacts due to autoxidation? 1979 Steroids pmid:494359