DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Nunes VS et al. HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C. 2011 Clin. Chim. Acta pmid:20932966
Wang L et al. Genome characterization of the oleaginous fungus Mortierella alpina. 2011 PLoS ONE pmid:22174787
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Pfeifer T et al. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. 2011 Curr Pharm Biotechnol pmid:21190543
Vanmierlo T et al. Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. 2011 Plant Foods Hum Nutr pmid:21431910
Hoenig MR et al. Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study. 2011 Lipids Health Dis pmid:21247428
Christophersen OA and Haug A Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. 2011 Lipids Health Dis pmid:21247506
Hajar R Statins: past and present. 2011 Heart Views pmid:22567201
Lin HY et al. Molecular basis for certain neuroprotective effects of thyroid hormone. 2011 Front Mol Neurosci pmid:22016721
Orsi M and Essex JW The ELBA force field for coarse-grain modeling of lipid membranes. 2011 PLoS ONE pmid:22194874
Wolff E et al. Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein -493 G/T polymorphism and the usual diet in women. 2011 Genes Nutr pmid:21437032
Cheng D et al. Lipid pathway alterations in Parkinson's disease primary visual cortex. 2011 PLoS ONE pmid:21387008
Kaddurah-Daouk R et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. 2011 PLoS ONE pmid:22022402
Matthan NR et al. Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. 2010 J. Lipid Res. pmid:19578163
Jiménez-López JM et al. Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. 2010 Lipids Health Dis pmid:20338039
Amaral C et al. Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:20630811
van Himbergen TM et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19834104
Mourvaki E et al. Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility. 2010 Asian J. Androl. pmid:20729867
Wei D et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. 2010 Diabetes pmid:19933995
Kim JH et al. Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. 2010 J. Neurochem. pmid:19860851