DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

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Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Lütjohann D et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. 2002 J. Lipid Res. pmid:12091492
Murphy KJ et al. Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis). 2002 Lipids pmid:12120958
Vaskonen T et al. Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet. 2002 Br. J. Nutr. pmid:12064332
Moghadasian MH et al. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. 2002 J. Clin. Pathol. pmid:12401826
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Andersson HC et al. Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. 2002 Am. J. Med. Genet. pmid:12457401
Berge KE et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. 2002 J. Lipid Res. pmid:11893785
Sudhop T et al. Serum plant sterols as a potential risk factor for coronary heart disease. 2002 Metab. Clin. Exp. pmid:12489060
Khripach VA et al. [Synthesis of C24-functionalized hydroxysterols]. 2002 May-Jun Bioorg. Khim. pmid:12077856
Cross NL Decrease in order of human sperm lipids during capacitation. 2003 Biol. Reprod. pmid:12700200
Westover EJ and Covey DF First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. 2003 Steroids pmid:12606007
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Juvet LK et al. On the role of liver X receptors in lipid accumulation in adipocytes. 2003 Mol. Endocrinol. pmid:12554745
Johnston JJ et al. Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. 2003 J. Agric. Food Chem. pmid:12502398
Okumura K et al. Formal synthesis of squalamine from desmosterol. 2003 Chem. Pharm. Bull. pmid:14519925
Miettinen TA and Gylling H Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. 2003 Eur. J. Clin. Invest. pmid:14636301
Pikuleva I and Javitt NB Novel sterols synthesized via the CYP27A1 metabolic pathway. 2003 Arch. Biochem. Biophys. pmid:14622972
Otte K et al. Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. 2003 Mol. Cell. Biol. pmid:12529392
Wechsler A et al. Generation of viable cholesterol-free mice. 2003 Science pmid:14684813
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643
Matthan NR et al. Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL. 2003 J. Lipid Res. pmid:12562840
Teunissen CE et al. Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. 2003 Jan-Feb Neurobiol. Aging pmid:12493560
Sánchez-Machado DI et al. An HPLC method for the quantification of sterols in edible seaweeds. 2004 Biomed. Chromatogr. pmid:15103705
Mutka AL et al. Secretion of sterols and the NPC2 protein from primary astrocytes. 2004 J. Biol. Chem. pmid:15355983
Yu H et al. Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. 2004 BMC Dev. Biol. pmid:15005800
Javitt NB Oxysteroids: a new class of steroids with autocrine and paracrine functions. 2004 Trends Endocrinol. Metab. pmid:15380811
Miller RR et al. Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success. 2004 Cryobiology pmid:15351685
Choi HS and Kim YW [Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells]. 2004 Korean J Gastroenterol pmid:15665577
Pihlajamäki J et al. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. 2004 J. Lipid Res. pmid:14657199
Luciani P et al. Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. 2004 J. Clin. Endocrinol. Metab. pmid:15001630
Sanocka D and Kurpisz M Reactive oxygen species and sperm cells. 2004 Reprod. Biol. Endocrinol. pmid:15038829
Yoder CA et al. Effectiveness of twenty, twenty-five diazacholesterol, avian gonadotropin-releasing hormone, and chicken riboflavin carrier protein for inhibiting reproduction in Coturnix quail. 2004 Poult. Sci. pmid:14979575
Gylling H et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. 2004 J. Lipid Res. pmid:15175352
Martin-Creuzburg D and Von Elert E Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. 2004 J. Chem. Ecol. pmid:15139303
Beasley CL et al. Reductions in cholesterol and synaptic markers in association cortex in mood disorders. 2005 Bipolar Disord pmid:16176438
Miller RR et al. Comparative aspects of sperm membrane fatty acid composition in silver (Vulpes vulpes) and blue (Alopex lagopus) foxes, and their relationship to cell cryopreservation. 2005 Cryobiology pmid:16040024
Phleger CF et al. Lipid composition of deep-sea hydrothermal vent tubeworm Riftia pachyptila, crabs Munidopsis subsquamosa and Bythograea thermydron, mussels Bathymodiolus sp. and limpets Lepetodrilus spp. 2005 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:15893489
Domeño C et al. Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID. 2005 Anal Bioanal Chem pmid:15827725
Chevy F et al. Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit. 2005 Prenat. Diagn. pmid:16231320
Scheidt HA et al. Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR. 2005 Biophys. J. pmid:16085761
Yu H and Patel SB Recent insights into the Smith-Lemli-Opitz syndrome. 2005 Clin. Genet. pmid:16207203
Levi O et al. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. 2005 J. Neurochem. pmid:16190879
Berring EE et al. A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study. 2005 Chem. Phys. Lipids pmid:15904906
Huster D et al. Desmosterol may replace cholesterol in lipid membranes. 2005 Biophys. J. pmid:15596512
Liu Y et al. Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. 2005 Mol. Endocrinol. pmid:15761033
Benvenuti S et al. Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. 2006 Exp. Cell Res. pmid:16762343
Hallikainen M et al. Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption. 2006 Clin. Chim. Acta pmid:16814761
Wang JH and Tuohimaa P Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells. 2006 Biochem. Biophys. Res. Commun. pmid:16696936
Ahmida HS et al. Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16807145
Mazalli MR et al. HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. 2006 Lipids pmid:16981439