DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Sánchez-Machado DI et al. An HPLC method for the quantification of sterols in edible seaweeds. 2004 Biomed. Chromatogr. pmid:15103705
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Yu H et al. Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. 2004 BMC Dev. Biol. pmid:15005800
Javitt NB Oxysteroids: a new class of steroids with autocrine and paracrine functions. 2004 Trends Endocrinol. Metab. pmid:15380811
Miller RR et al. Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success. 2004 Cryobiology pmid:15351685
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Cross NL Decrease in order of human sperm lipids during capacitation. 2003 Biol. Reprod. pmid:12700200
Westover EJ and Covey DF First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. 2003 Steroids pmid:12606007
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Johnston JJ et al. Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife. 2003 J. Agric. Food Chem. pmid:12502398
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Phleger CF et al. Interannual and between species comparison of the lipids, fatty acids and sterols of Antarctic krill from the US AMLR Elephant Island survey area. 2002 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11923086
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Moghadasian MH et al. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. 2002 J. Clin. Pathol. pmid:12401826
Fernández C et al. Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. 2002 Biochem. J. pmid:12162789
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Andersson HC et al. Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. 2002 Am. J. Med. Genet. pmid:12457401
Berge KE et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. 2002 J. Lipid Res. pmid:11893785
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Hallikainen M et al. Short-term LDL cholesterol-lowering efficacy of plant stanol esters. 2002 BMC Cardiovasc Disord pmid:12197945
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Waterham HR et al. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. 2001 Am. J. Hum. Genet. pmid:11519011
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Tammi A et al. Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study. 2001 Pediatr. Res. pmid:11726725
Sion B et al. Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography. 2001 J Chromatogr A pmid:11762778
Tammi A et al. Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. 2001 J. Nutr. pmid:11435511
Phleger CF et al. Interannual variations in the lipids of the Antarctic pteropods Clione limacina and Clio pyramidata. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11250551
Serfis AB et al. Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films. 2001 Biochim. Biophys. Acta pmid:11286977
Lindenthal B et al. Progestins block cholesterol synthesis to produce meiosis-activating sterols. 2001 FASEB J. pmid:11259396
Lindenthal B et al. Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. 2001 J. Lipid Res. pmid:11441136
Moebius FF et al. Genetic defects in postsqualene cholesterol biosynthesis. 2000 Trends Endocrinol. Metab. pmid:10707051
Fliesler SJ et al. Retinal structure and function in an animal model that replicates the biochemical hallmarks of desmosterolosis. 2000 Neurochem. Res. pmid:10905631