DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chitwood DJ et al. | Novel nuclear methylation of sterols by the nematode Caenorhabditis elegans. | 1983 | Steroids | pmid:6673193 |
| Goh EH | Transfer of exogenous cholesterol to microsomes of hepatocytes investigated with [3H]desmosterol tracer. | 1983 | Biochem. J. | pmid:6651772 |
| Pullinger CR and Gibbons GF | The relationship between the rate of hepatic sterol synthesis and the incorporation of [3H]water. | 1983 | J. Lipid Res. | pmid:6644182 |
| Schroeder F et al. | Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497882 |
| Leonard DA and Chen HW | Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells. | 1984 | J. Biol. Chem. | pmid:6425279 |
| Huijmans JG et al. | Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. | 1981 | Acta Endocrinol. | pmid:6263029 |
| Bouthillier M et al. | Distribution of steroid sulfotransferase in the male hamster reproductive tract. | 1984 | Biol. Reprod. | pmid:6240284 |
| Fumagalli R et al. | [Markers of brain tumors]. | 1984 | Minerva Med. | pmid:6203056 |
| Sarkar CP and Cenedella RJ | Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. | 1982 | Lipids | pmid:6177997 |
| Wasserstrom WR et al. | Cerebrospinal fluid biochemical markers in central nervous system tumors: a review. | 1981 May-Jun | Ann. Clin. Lab. Sci. | pmid:6166240 |