DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Arnold A et al. Triparanol-effected accumulation of desmosterol in oestrone-induced hypocholesterolaemia. 1974 J. Pharm. Pharmacol. pmid:4156546
Jeng I et al. Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. 1985 Biochem. Pharmacol. pmid:3994747
Pentchev PG et al. The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. 1986 J. Biol. Chem. pmid:3949747
Chen JK et al. Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. 1986 Exp. Cell Res. pmid:3943557
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. 1979 J. Natl. Cancer Inst. pmid:384010
Vuoristo M and Miettinen TA Serum cholesterol precursor sterols in coeliac disease: effects of gluten free diet and cholestyramine. 1986 Gut pmid:3792914
Bernini F et al. Selected ion monitoring technique for the evaluation of sterols in cerebrospinal fluid: a new approach to desmosterol test for central nervous system tumors. 1986 J. Neurooncol. pmid:3746383
Björkhem I et al. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. 1987 J. Lipid Res. pmid:3681138
Bhattacharyya AK and Eggen DA Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys. 1987 Atherosclerosis pmid:3675704
Roberts KD Sterol sulfates in the epididymis; synthesis and possible function in the reproductive process. 1987 J. Steroid Biochem. pmid:3480393
Slotte JP and Bierman EL Movement of plasma-membrane sterols to the endoplasmic reticulum in cultured cells. 1987 Biochem. J. pmid:3435441
Bouthillier M et al. The assay and partial characterization of 3 beta-hydroxysteroid sulfotransferase of the hamster epididymis. 1985 Can. J. Biochem. Cell Biol. pmid:3157430
Müller C et al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. 2017 Eur J Med Chem pmid:28964935
Simonen P et al. Desmosterol accumulation in users of amiodarone. 2018 J. Intern. Med. pmid:28861933
Mouritsen OG et al. Effects of seaweed sterols fucosterol and desmosterol on lipid membranes. 2017 Chem. Phys. Lipids pmid:28365392
Hamdan IJA et al. Sterols in infant formulas: validation of a gas chromatographic method. 2017 Int J Food Sci Nutr pmid:28276904
Albers HK et al. [The problem of characterization of sterins in the gingiva by means of gas chromatography--mass spectrometry]. 1978 Dtsch Zahnarztl Z pmid:280451
Svoboda JA et al. Intermediates of stigmasterol metabolism in Spodoptera littoralis. 1989 Mar-May Steroids pmid:2799849
Costello DA et al. Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. 2016 ACS Infect Dis pmid:27933788
Awano M et al. Identification of cholesta-7,24-dien-3 beta-ol and desmosterol in hamster cauda epididymal spermatozoa. 1989 Lipids pmid:2779373