DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DESMOSTEROL

Download all related citations
Per page 10 20 50 100 | Total 433
Authors Title Published Journal PubMed Link
Grossi-Paoletti E et al. Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics. 1972 J. Neurosurg. pmid:5076376
Tammi A et al. Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. 2001 J. Nutr. pmid:11435511
Dasgupta SK et al. New preparation of desmosterol. 1974 J. Org. Chem. pmid:4853344
Hedman M et al. Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. 2006 J. Pediatr. pmid:16492436
Arnold A et al. Triparanol-effected accumulation of desmosterol in oestrone-induced hypocholesterolaemia. 1974 J. Pharm. Pharmacol. pmid:4156546
Griffiths WJ et al. Discovering oxysterols in plasma: a window on the metabolome. 2008 J. Proteome Res. pmid:18605750
Awano M et al. Lipid composition of hamster epididymal spermatozoa. 1993 J. Reprod. Fertil. pmid:8107019
Burck PJ and Zimmerman RE The inhibition of acrosin by sterol sulphates. 1980 J. Reprod. Fertil. pmid:6987395
Bleau G et al. Desmosteryl sulphate of hamster spermatozoa, a potent inhibitor of capacitation in vitro. 1975 J. Reprod. Fertil. pmid:1127634
Roberts KD Sterol sulfates in the epididymis; synthesis and possible function in the reproductive process. 1987 J. Steroid Biochem. pmid:3480393
Serra M et al. Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. 2010 J. Steroid Biochem. Mol. Biol. pmid:20804844
Fon Tacer K et al. Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. 2010 J. Steroid Biochem. Mol. Biol. pmid:20206258
Samuli Ollila OH et al. Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. 2007 J. Struct. Biol. pmid:17369050
Wudiri GA et al. Molecular requirement for sterols in herpes simplex virus entry and infectivity. 2014 J. Virol. pmid:25231306
Doi O and Endo A Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium. 1978 Jpn. J. Med. Sci. Biol. pmid:732030
Choi HS and Kim YW [Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells]. 2004 Korean J Gastroenterol pmid:15665577
AVIGAN J and STEINBERG D Deposition of desmosterol in the lesions of experimental atherosclerosis. 1962 Lancet pmid:13863404
Clayton P et al. Desmosterolosis: a new inborn error of cholesterol biosynthesis. 1996 Lancet pmid:8709748
Fleisher JH et al. Cholesterol in cerebrospinal fluid of brain tumor patients. 1973 Life Sci. pmid:4358663
Barbosa SP et al. Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive protein. 2013 Life Sci. pmid:23507424
Kuksis A et al. Identification of plant sterols in plasma and red blood cells of man and experimental animals. 1976 Lipids pmid:972575
Svoboda JA et al. Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines. 1977 Lipids pmid:909356
Fliesler SJ et al. Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition. 2000 Lipids pmid:10783006
Weete JD and Gandhi SR Sterols of the phylum zygomycota: phylogenetic implications. 1997 Lipids pmid:9438242
Murphy KJ et al. Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis). 2002 Lipids pmid:12120958
Clark RM et al. Desmosterol in human milk. 1983 Lipids pmid:6855485
Goh EH et al. HPLC analysis of desmosterol, 7-dehydrocholesterol, and cholesterol. 1989 Lipids pmid:2779370
Goh EH et al. Analysis of cholesterol and desmosterol in cultured cells without organic solvent extraction. 1990 Lipids pmid:2280678
Awano M et al. Identification of cholesta-7,24-dien-3 beta-ol and desmosterol in hamster cauda epididymal spermatozoa. 1989 Lipids pmid:2779373
Sekula BC and Nes WR Metabolism of sterols by anaerobic Saccharomyces cerevisiae. 1981 Lipids pmid:7012521
Svoboda JA et al. Utilization and metabolism of dietary sterols in the honey bee and the yellow fever mosquito. 1982 Lipids pmid:7087696
Shah SN Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D-C) ratio in developing rat brain. 1972 Lipids pmid:5084158
Sarkar CP and Cenedella RJ Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. 1982 Lipids pmid:6177997
Mazalli MR et al. HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. 2006 Lipids pmid:16981439
Ramsey RB Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. 1977 Lipids pmid:72342
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Jiménez-López JM et al. Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. 2010 Lipids Health Dis pmid:20338039
Hoenig MR et al. Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study. 2011 Lipids Health Dis pmid:21247428
Christophersen OA and Haug A Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. 2011 Lipids Health Dis pmid:21247506
Likhodii SS and Cunnane SC Utilization of carbon from dietary polyunsaturates for brain cholesterol synthesis during early postnatal development in the rat: a 13C NMR study. 1995 Magn Reson Med pmid:8598807
Aknin M et al. Sterols from the Madagascar sponge Fascaplysinopsis sp. 2010 Mar Drugs pmid:21339959
Gylling H et al. Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease. 2006 Mar-Apr Menopause pmid:16645542
Pihlajamäki J et al. Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding. 2010 Metab. Clin. Exp. pmid:20015521
Lindenthal B et al. Influence of simvastatin, pravastatin, and BM 15.766 on neutral sterols in liver and testis of guinea pigs. 2002 Metab. Clin. Exp. pmid:11912560
Gylling H et al. Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. 1991 Metab. Clin. Exp. pmid:1984567
Sudhop T et al. Serum plant sterols as a potential risk factor for coronary heart disease. 2002 Metab. Clin. Exp. pmid:12489060
Fumagalli R et al. [Markers of brain tumors]. 1984 Minerva Med. pmid:6203056
Otte K et al. Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. 2003 Mol. Cell. Biol. pmid:12529392
Juvet LK et al. On the role of liver X receptors in lipid accumulation in adipocytes. 2003 Mol. Endocrinol. pmid:12554745
Liu Y et al. Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. 2005 Mol. Endocrinol. pmid:15761033