DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Levi O et al. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. 2005 J. Neurochem. pmid:16190879
Kim JH et al. Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. 2010 J. Neurochem. pmid:19860851
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Seidenfeld J and Marton LJ Biochemical markers of central nervous system tumors measured in cerebrospinal fluid and their potential use in diagnosis and patient management: a review. 1979 J. Natl. Cancer Inst. pmid:384010
Sheu JH et al. Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata. 1996 J. Nat. Prod. pmid:8984148
Lütjohann D et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. 2002 J. Lipid Res. pmid:12091492
Pullinger CR and Gibbons GF The relationship between the rate of hepatic sterol synthesis and the incorporation of [3H]water. 1983 J. Lipid Res. pmid:6644182
Meljon A et al. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. 2012 J. Lipid Res. pmid:22891291
Nes WR et al. Steric effects at C-20 and C-24 on the metabolism of sterols by Tetrahymena pyriformis. 1981 J. Lipid Res. pmid:6793681
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Björkhem I et al. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. 1987 J. Lipid Res. pmid:3681138
McDonald JG et al. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. 2012 J. Lipid Res. pmid:22517925
Berge KE et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. 2002 J. Lipid Res. pmid:11893785
Goyal S et al. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. 2014 J. Lipid Res. pmid:25017465
Sato Y et al. Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. 2012 J. Lipid Res. pmid:22203775
Bentzen CL and Brendel K Synthesis of [24, 25-3H]cholesterol: a new substrate for determining the rate of cholesterol side chain oxidation. 1979 J. Lipid Res. pmid:438651
Bhattacharyya AK and Eggen DA Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol. 1981 J. Lipid Res. pmid:7217781
Lindenthal B et al. Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. 2001 J. Lipid Res. pmid:11441136