DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Svoboda JA et al. Reduction of blood and liver cholesterol in the rat by straight and branched chain alkyl amines. 1977 Lipids pmid:909356
Saito Y et al. Animal cell mutants defective in sterol metabolism: a specific selection procedure and partial characterization of defects. 1977 Proc. Natl. Acad. Sci. U.S.A. pmid:269426
Ramsey RB et al. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. 1977 J. Neurochem. pmid:874494
Gibbons GF and Pullinger CR Measurement of the absolute rates of cholesterol biosynthesis in isolated rat liver cells. 1977 Biochem. J. pmid:849287
Abernethy DR and Azarnoff DL Effect of drugs which alter microsomal drug-metabolizing enzyme activity on rat hepatic cholesterol biosynthesis. 1977 Biochem. Pharmacol. pmid:849344
Ochi K et al. Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. 1977 Steroids pmid:611642
Ramsey RB Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat. 1977 Lipids pmid:72342
Kuksis A et al. Identification of plant sterols in plasma and red blood cells of man and experimental animals. 1976 Lipids pmid:972575
Lalumière G et al. Cholesteryl sulfate and sterol sulfatase in the human reproductive tract. 1976 Steroids pmid:1273889
Pleasure D and Kim SU Sterol synthesis by myelinating cultures of mouse spinal cord. 1976 Brain Res. pmid:175882
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Arthur JR et al. Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue. 1976 Biochem. J. pmid:986816
Sweasey D et al. Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig. 1976 J. Neurochem. pmid:965978
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Awata N et al. Carbon-carbon bond cleavage of fucosterol-24, 28-oxide by cell-free extracts of silkworm Bombyx mori. 1975 Biochem. Biophys. Res. Commun. pmid:167728
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Nagatomo T and Peter JB (Na+ + K+)-ATPase activity in rats with 20, 25-diazacholesterol-induced myotonia. 1975 Exp. Neurol. pmid:123512
Svoboda JA et al. Recent developments in insect steroid metabolism. 1975 Annu. Rev. Entomol. pmid:1091201
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Johnson RC and Shah SN Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. 1974 Arch. Biochem. Biophys. pmid:4460877
Kobayashi M and Mitsuhashi H Marine sterols. V. Isolation and structure of occelasterol, a new 27-norergostane-type sterol, from an annelida, Pseudopotamilla occelata. 1974 Steroids pmid:4370183
Smith AG and Goad LJ Sterol biosynthesis by the sea urchin Echinus esculentus. 1974 Biochem. J. pmid:4441383
Ramsey RB and Davison AN Steryl esters and their relationship to normal and diseased human central nervous system. 1974 J. Lipid Res. pmid:4363969
Parks LW et al. Sterol transmethylation during aerobic adaptation of yeast. 1974 Eur. J. Biochem. pmid:4598750
Morisaki M et al. Nutritional effect of possible intermediates of phytosterol dealkylation in the silkworm, Bombyx mori. 1974 Steroids pmid:4421556
Dennick RG et al. Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. 1974 J. Neurochem. pmid:4854410
Watson KC and Kerr EJ Sterol structural requirements for inhibition of streptolysin O activity. 1974 Biochem. J. pmid:4451554
Dennick RG et al. The occurrence of desmosterol in neuronal and glial fractions from developing rat brain. 1974 FEBS Lett. pmid:4213464
Bleau G and VandenHeuvel WJ Desmosteryl sulfate and desmosterol in hamster epididymal spermatozoa. 1974 Steroids pmid:4423229
Brennan PJ et al. The lipids of fungi. 1974 Prog Chem Fats Other Lipids pmid:4610639
Bates SR and Rothblat GH Regulation of cellular sterol flux and synthesis by human serum lipoproteins. 1974 Biochim. Biophys. Acta pmid:4369129
Croce CM et al. Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts. 1974 Proc. Natl. Acad. Sci. U.S.A. pmid:4359325
Harris PA and Harris KL Quantitative GLC analysis of plasma cholesterol. 1974 J Pharm Sci pmid:4830004
Arnold A et al. Triparanol-effected accumulation of desmosterol in oestrone-induced hypocholesterolaemia. 1974 J. Pharm. Pharmacol. pmid:4156546
Dasgupta SK et al. New preparation of desmosterol. 1974 J. Org. Chem. pmid:4853344
Fumagalli R et al. [Desmosterol test in the diagnosis of recurrent brain neoplasms]. 1973 May-Jun Acta Neurol (Napoli) pmid:4732487
Imai Y and Shimamoto K Biological studies of AT-308. 1. Hypocholesterolemic effect of 1,2,4-oxadiazole derivatives in rats. 1973 Jan-Feb Atherosclerosis pmid:4696738
Fiehn W et al. ATPases of erythrocytes from rats with 20, 25-diazacholesterol induced myotonia. 1973 FEBS Lett. pmid:4270614
Ener MA and Frantz ID Chemical synthesis of delta 7,24-(3alpha-3H)cholestadien-3beta-ol and its conversion to cholesterol in the rat. 1973 J. Biol. Chem. pmid:4355504
Jurgelski W et al. Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis. 1973 Brain Res. pmid:4798641
Norton WT and Poduslo SE Myelination in rat brain: changes in myelin composition during brain maturation. 1973 J. Neurochem. pmid:4754856
Herz JE and Cruz Montalvo S Fluorinated sterols. 1. 26,26,26,27,27,27-Hexafluorodesmosterol. 1973 J. Chem. Soc. Perkin Trans. I pmid:4795247
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