DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Nagy K et al. Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics. 2006 Rapid Commun. Mass Spectrom. pmid:16841361
Legg RL et al. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. 2008 Reprod. Biol. Endocrinol. pmid:19025659
Sanocka D and Kurpisz M Reactive oxygen species and sperm cells. 2004 Reprod. Biol. Endocrinol. pmid:15038829
Peter JB and Fiehn W Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. 1973 Science pmid:4265797
Wechsler A et al. Generation of viable cholesterol-free mice. 2003 Science pmid:14684813
Kobayashi M and Mitsuhashi H Marine sterols. V. Isolation and structure of occelasterol, a new 27-norergostane-type sterol, from an annelida, Pseudopotamilla occelata. 1974 Steroids pmid:4370183
Lalumière G et al. Cholesteryl sulfate and sterol sulfatase in the human reproductive tract. 1976 Steroids pmid:1273889
Zhao Q et al. A highly stereoselective synthesis of C-24 and C-25 oxysterols from desmosterol. 2016 Steroids pmid:26968128
Zhao Q et al. Investigation on the synthesis of 25-hydroxycholesterol. 2014 Steroids pmid:24582707
Chitwood DJ et al. Novel nuclear methylation of sterols by the nematode Caenorhabditis elegans. 1983 Steroids pmid:6673193
Westover EJ and Covey DF First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. 2003 Steroids pmid:12606007
Legault Y et al. 5alpha-Cholesta-7,24-dien-3beta-ol as a major sterol of the male hamster reproductive tract. 1978 Steroids pmid:734699
Morisaki M et al. Nutritional effect of possible intermediates of phytosterol dealkylation in the silkworm, Bombyx mori. 1974 Steroids pmid:4421556
Bleau G and VandenHeuvel WJ Desmosteryl sulfate and desmosterol in hamster epididymal spermatozoa. 1974 Steroids pmid:4423229
Zeeck E et al. Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea. 1994 Steroids pmid:8073448
Svoboda JA et al. Intermediates of stigmasterol metabolism in Spodoptera littoralis. 1989 Mar-May Steroids pmid:2799849
Legault Y et al. The binding of sterol sulfates to hamster spermatozoa. 1979 Steroids pmid:483338
Francisco C et al. Side chain-hydroxylated sterols of the red alga Asparagopsis armata: significant products or artifacts due to autoxidation? 1979 Steroids pmid:494359
Ochi K et al. Synthesis of desmosterol and epidesmosterol from hyodeoxycholic acid. 1977 Steroids pmid:611642
Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Pedretti A et al. Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations. 2008 Steroids pmid:18394665
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Yin L et al. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. 2016 Toxicol In Vitro pmid:26820058
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Cubells L et al. Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex. 2007 Traffic pmid:17822395
Siperstein MD The relationship of cholesterol biosynthesis to cancer. 1972 Trans. Am. Clin. Climatol. Assoc. pmid:4340647
Siirtola A et al. Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. 2006 Transplantation pmid:16477216
Javitt NB Oxysteroids: a new class of steroids with autocrine and paracrine functions. 2004 Trends Endocrinol. Metab. pmid:15380811
Moebius FF et al. Genetic defects in postsqualene cholesterol biosynthesis. 2000 Trends Endocrinol. Metab. pmid:10707051
Palamarchuk VI and Koval' VG [Isolation and identification of desmosterol and its concentration in animal brain tissue]. 1977 Mar-Apr Ukr Biokhim Zh pmid:867530
Seiler D et al. [Effect of sterol composition on the activity of transport-ATPase of the erythrocyte membrane]. 1975 Verh Dtsch Ges Inn Med pmid:132802
Furtula V et al. Inorganic nitrogen, sterols and bacterial source tracking as tools to characterize water quality and possible contamination sources in surface water. 2012 Water Res. pmid:22197263
Fujimoto Y et al. [Studies on the biosynthesis of sterol side chain in higher plants]. 2000 Yakugaku Zasshi pmid:11082699