DESMOSTEROL

DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DESMOSTEROL?

DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DESMOSTEROL

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Coronary Disease D003327 70 associated lipids
Celiac Disease D002446 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Insulin Resistance D007333 99 associated lipids
Limb Deformities, Congenital D017880 4 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with DESMOSTEROL

Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DESMOSTEROL?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DESMOSTEROL?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DESMOSTEROL?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DESMOSTEROL?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DESMOSTEROL?

Transgenic Model

Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DESMOSTEROL

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Authors Title Published Journal PubMed Link
Peter JB and Fiehn W Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. 1973 Science pmid:4265797
Johnson RC and Shah SN Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. 1973 Biochem. Biophys. Res. Commun. pmid:4741538
Bojesen I and Roepstorff P Identification of C sterols produced by rat renal inner medulla in vitro. 1973 Biochim. Biophys. Acta pmid:4722467
Dennick RG et al. Desmosterol levels in human foetal brain--a reassessment. 1973 J. Neurochem. pmid:4697890
Fleisher JH et al. Cholesterol in cerebrospinal fluid of brain tumor patients. 1973 Life Sci. pmid:4358663
Jurgelski W et al. Induction of a chronic somatosensory epilepsy in the opossum (Didelphis virginiana Kerr) with an inhibitor of cholesterol biosynthesis. 1973 Brain Res. pmid:4798641
Sokoloff L and Rothblat GH Regulation of sterol synthesis in L cells: steady-state and transitional responses. 1972 Biochim. Biophys. Acta pmid:5070653
Surpuriya V and Higuchi WI Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface. 1972 Biochim. Biophys. Acta pmid:4640769
Siperstein MD The relationship of cholesterol biosynthesis to cancer. 1972 Trans. Am. Clin. Climatol. Assoc. pmid:4340647
Singh RA et al. Effect of azasterols on sterol metabolism in the laying hen. 1972 Poult. Sci. pmid:4643119
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Akhtar M et al. A novel olefinic rearrangement. The enzymic conversion of cholesta-7,9-dien-3 -ol into cholesta-8,14-dien-3 -ol. 1972 Biochem. J. pmid:4404936
Shah SN Effect of neonatal food restriction and hyperphenylalaninemia on desmosterol to cholesterol (D-C) ratio in developing rat brain. 1972 Lipids pmid:5084158
Wakamatsu H et al. Concentration and fatty acid composition of serum lipids in myotonia dystrophica. With special reference to pathogenesis. 1972 Horm. Metab. Res. pmid:4655500
Grossi-Paoletti E et al. Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics. 1972 J. Neurosurg. pmid:5076376
Ikan R et al. Synthesis of steroidal cyclopropanes. 1972 J. Chem. Soc. Perkin Trans. I pmid:4674538
Leboeuf M et al. [Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material]. 1972 Ann Pharm Fr pmid:4668289
Svoboda JA and Thompson MJ Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations. 1967 J. Lipid Res. pmid:14564725
CHOBANIAN AV and HOLLANDER W TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY. 1965 J. Lipid Res. pmid:14280470
WHITBY LG et al. THE ESTIMATION OF DESMOSTEROL AND CHOLESTEROL IN PLASMA. 1964 Br Heart J pmid:14132032
POTTIER J and BUSIGNY M [DETERMINATION OF DESMOSTEROL IN SERUM]. 1964 Clin. Chim. Acta pmid:14231926
HERNDON JH and SIPERSTEIN MD Desmosterol deposition in human and experimental atherosclerosis. 1963 Circ. Res. pmid:13953991
GOODMAN DS et al. The in vitro metabolism of desmosterol with adrenal and liver preparations. 1962 J. Clin. Invest. pmid:13949087
AVIGAN J and STEINBERG D Deposition of desmosterol in the lesions of experimental atherosclerosis. 1962 Lancet pmid:13863404
FISH WA et al. Metabolism of cholesterol in the chick embryo. III. Localization and turnover of desmosterol (24-dehydrocholesterol). 1962 J. Biol. Chem. pmid:13893200
GOODMAN DS et al. The metabolism of desmosterol in human subjects during triparanol administration. 1962 J. Clin. Invest. pmid:13900301
SACHS BA and WOLFMAN L Studies of serum desmosterol levels in hypercholesteremic subjects treated with triparanol (MER-29). 1961 Nov-Dec Am. J. Clin. Nutr. pmid:14495832
AVIGAN J and STEINBERG D Studies of cholesterol biosynthesis. III. The desmosterol reductase system in liver. 1961 J. Biol. Chem. pmid:13863405
AVIGAN J et al. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. 1960 J. Biol. Chem. pmid:13685286
STEINBERG D et al. Identification of 24-dehydrocholesterol in the serum of patients treated with MER-29. 1960 Prog Cardiovasc Dis pmid:13834161
STOKES WM et al. Sterol metabolism. I. The occurrence of desmosterol (24-dehydrocholesterol) in rat skin and its conversion in vivo to cholesterol. 1958 J. Biol. Chem. pmid:13549424
Hoenig MR et al. The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort. J Clin Lipidol pmid:21392722
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