| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jeschke MG et al. | The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes. | 2012 | PLoS ONE | pmid:22606232 |
| Weeks AC et al. | Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin. | 2012 | Curr. Eye Res. | pmid:22050601 |
| Tansley G et al. | Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. | 2012 | Curr Gerontol Geriatr Res | pmid:22649448 |
| Baardman ME et al. | The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport? | 2012 | Am. J. Obstet. Gynecol. | pmid:22728028 |
| van den Kommer TN et al. | The role of extracerebral cholesterol homeostasis and ApoE e4 in cognitive decline. | 2012 | Neurobiol. Aging | pmid:21482441 |
| Besga A et al. | Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms. | 2012 | Neurosci. Lett. | pmid:22281444 |
| Shichiri M et al. | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. | 2012 | J. Biol. Chem. | pmid:22147702 |
| Hooff GP et al. | Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. | 2012 | Mol. Neurobiol. | pmid:22692983 |
| Yao X et al. | Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. | 2012 | Planta Med. | pmid:22961117 |
| Clark PJ et al. | Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. | 2012 | Hepatology | pmid:22318926 |
| Wang N et al. | Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. | 2012 | Planta Med. | pmid:22948612 |
| Zhao FQ et al. | [Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4]. | 2012 | Yao Xue Xue Bao | pmid:22812017 |
| Gai YY et al. | Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats. | 2012 | J Ethnopharmacol | pmid:22771280 |
| Parisio G et al. | Flip-flop of steroids in phospholipid bilayers: effects of the chemical structure on transbilayer diffusion. | 2012 | J. Am. Chem. Soc. | pmid:22738146 |
| Howard AL et al. | Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence. | 2012 | Arch. Biochem. Biophys. | pmid:22446159 |
| Du YC et al. | Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. | 2012 | Phytomedicine | pmid:22516893 |
| Kořený L et al. | Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22355128 |
| Liu RM et al. | Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro. | 2012 | Eur. J. Pharmacol. | pmid:22366428 |
| Singh R et al. | HILIC quantification of oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages. | 2012 | J Ethnopharmacol | pmid:22414479 |
| You BJ et al. | Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878212 |
| D'Agostino J et al. | Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. | 2012 | J. Biol. Chem. | pmid:22453923 |
| Fakheri RJ and Javitt NB | 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. | 2012 | Steroids | pmid:22366074 |
| Hoshino T et al. | Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring. | 2012 | Chemistry | pmid:22933236 |
| Silbernagel G et al. | Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. | 2012 | Exp Diabetes Res | pmid:22203835 |
| Vallejo MC et al. | Lipidomic analysis of extracellular vesicles from the pathogenic phase of Paracoccidioides brasiliensis. | 2012 | PLoS ONE | pmid:22745761 |
| Kushima H et al. | Cloning of the lanosterol 14-α-demethylase ( ERG11 ) gene in Trichosporon asahii: a possible association between G453R amino acid substitution and azole resistance in T. asahii. | 2012 | FEMS Yeast Res. | pmid:22621704 |
| Hartwig T et al. | Propiconazole is a specific and accessible brassinosteroid (BR) biosynthesis inhibitor for Arabidopsis and maize. | 2012 | PLoS ONE | pmid:22590578 |
| Tebbets B et al. | Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. | 2012 | PLoS ONE | pmid:22574132 |
| Cook CC et al. | Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer. | 2012 | Cell Death Dis | pmid:22258408 |
| Vandeputte P et al. | Antifungal resistance and new strategies to control fungal infections. | 2012 | Int J Microbiol | pmid:22187560 |
| Nes CR et al. | Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. | 2012 | Biochem. J. | pmid:22176028 |
| Miller MB et al. | Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. | 2012 | J. Lipid Res. | pmid:22591742 |
| Liu YT et al. | Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase. | 2012 | Org. Lett. | pmid:23043506 |
| Dutra RC et al. | Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms. | 2012 | Biochem. Pharmacol. | pmid:22155310 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Choi KY et al. | Novel iron-sulfur containing NADPH-reductase from Nocardia farcinica IFM10152 and fusion construction with CYP51 lanosterol demethylase. | 2012 | Biotechnol. Bioeng. | pmid:22038382 |
| Wang JL et al. | Enhanced recovery of antitumor ganoderic acid T from Ganoderma lucidum mycelia by novel chemical conversion strategy. | 2012 | Biotechnol. Bioeng. | pmid:22038732 |
| Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
| Wang Y et al. | Simultaneous determination of cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside in beagle dog plasma by LC-MS/MS. | 2012 | J Pharm Biomed Anal | pmid:22285707 |
| Du D et al. | Rapid isolation and purification of inotodiol and trametenolic acid from Inonotus obliquus by high-speed counter-current chromatography with evaporative light scatting detection. | 2011 Sep-Oct | Phytochem Anal | pmid:21433158 |
| Das J et al. | Oral itraconazole for the treatment of severe seborrhoeic dermatitis. | 2011 Sep-Oct | Indian J Dermatol | pmid:22121267 |
| Nkinin SW et al. | Pneumocystis carinii sterol 14α-demethylase activity in Saccharomyces cerevisiae erg11 knockout mutant: sterol biochemistry. | 2011 Jul-Aug | J. Eukaryot. Microbiol. | pmid:21569162 |
| Acero FJ et al. | Development of proteomics-based fungicides: new strategies for environmentally friendly control of fungal plant diseases. | 2011 | Int J Mol Sci | pmid:21340014 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Nacev BA and Liu JO | Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole. | 2011 | PLoS ONE | pmid:21969860 |
| Ogbuewu IP et al. | The potentiality of medicinal plants as the source of new contraceptive principles in males. | 2011 | N Am J Med Sci | pmid:22540095 |
| Boone LR et al. | Mechanism of resistance to dietary cholesterol. | 2011 | J Lipids | pmid:22007308 |
| Hoot SJ et al. | The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity. | 2011 | BMC Microbiol. | pmid:21951709 |
| Bisi-Johnson MA et al. | Evaluation of the antibacterial and anticancer activities of some South African medicinal plants. | 2011 | BMC Complement Altern Med | pmid:21329526 |
| Leoni V et al. | Whole body cholesterol metabolism is impaired in Huntington's disease. | 2011 | Neurosci. Lett. | pmid:21406216 |