MeSH term | MeSH ID | Detail |
---|---|---|
Abetalipoproteinemia | D000012 | 7 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Abetalipoproteinemia | D000012 | 7 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cooper AB et al. | Synthesis and antifungal properties of 14-aminomethyl-substituted lanosterol derivatives. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3214062 |
Schroepfer GJ | Sterol biosynthesis. | 1982 | Annu. Rev. Biochem. | pmid:6810750 |
Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
Nomura M et al. | Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. | 2008 Sep-Oct | Anticancer Res. | pmid:19035296 |
Parker JE et al. | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. | 2008 | Antimicrob. Agents Chemother. | pmid:18694951 |
Van den Bossche H et al. | In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. | 1980 | Antimicrob. Agents Chemother. | pmid:6250469 |
Warrilow AG et al. | The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. | 2016 | Antimicrob. Agents Chemother. | pmid:27161631 |
Sagatova AA et al. | Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase. | 2015 | Antimicrob. Agents Chemother. | pmid:26055382 |
Buurman ET et al. | Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds. | 2005 | Antimicrob. Agents Chemother. | pmid:15917573 |
Sud IJ and Feingold DS | Heterogeneity of action of mechanisms among antimycotic imidazoles. | 1981 | Antimicrob. Agents Chemother. | pmid:6269485 |