lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Abetalipoproteinemia D000012 7 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
Kölsch H et al. Alterations of cholesterol precursor levels in Alzheimer's disease. 2010 Biochim. Biophys. Acta pmid:20226877
Ponmanickam P et al. Identification of testosterone-dependent volatile compounds and proteins in the preputial gland of rat Rattus norvegicus. 2010 Gen. Comp. Endocrinol. pmid:20211182
Wang F et al. Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads. 2010 Prostaglandins Other Lipid Mediat. pmid:20193772
Urzúa U et al. Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis. 2010 BMC Genomics pmid:21210965
Sun C et al. De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. 2010 BMC Genomics pmid:20416102
Cavalier-Smith T Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. 2010 Biol. Direct pmid:20132544
Brumfield KM et al. Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. 2010 PLoS ONE pmid:20084111
Lu X et al. Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. 2010 J. Sci. Food Agric. pmid:20355042
Lee CH et al. Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea. 2010 J. Agric. Food Chem. pmid:20334412
Morio F et al. Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. 2010 Diagn. Microbiol. Infect. Dis. pmid:20226328
Sheng C et al. Improved model of lanosterol 14alpha-demethylase by ligand-supported homology modeling: validation by virtual screening and azole optimization. 2010 ChemMedChem pmid:20157915
Koivusalo AI et al. Cholesterol, non-cholesterol sterols and bile acids in paediatric gallstones. 2010 Dig Liver Dis pmid:19632165
Targett-Adams P et al. Lipid metabolism and HCV infection. 2010 Viruses pmid:21994676
Kimura M et al. Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. 2010 Biochem. Biophys. Res. Commun. pmid:19951700
Yadav VR et al. Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. 2010 Toxins (Basel) pmid:22069560
Serra M et al. Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. 2010 J. Steroid Biochem. Mol. Biol. pmid:20804844
De Luca C and Valacchi G Surface lipids as multifunctional mediators of skin responses to environmental stimuli. 2010 Mediators Inflamm. pmid:20981292
Brockington A et al. Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis. 2010 BMC Genomics pmid:20346106
Handa N et al. An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus. 2010 Phytochemistry pmid:20691456
Wang JL et al. A new ganoderic acid from Ganoderma lucidum mycelia. 2010 J Asian Nat Prod Res pmid:20706913
Ding N et al. Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis. 2010 J Pharm Biomed Anal pmid:20719456
Kim JH et al. Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. 2010 J. Neurochem. pmid:19860851
Shi L et al. Current progress in the study on biosynthesis and regulation of ganoderic acids. 2010 Appl. Microbiol. Biotechnol. pmid:20859739
Noel JP et al. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. 2010 ACS Chem. Biol. pmid:20175559
Taramino S et al. Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. 2010 Biochim. Biophys. Acta pmid:20659585
Straud S et al. Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. 2010 PLoS ONE pmid:20661293
Marco-Jiménez F et al. Effects of lanosterol on in vitro maturation of porcine oocytes. 2010 Anim. Reprod. Sci. pmid:19473792
Aono T et al. Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials. 2010 J. Biomed. Sci. pmid:21129218
Zoller E et al. Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections. 2010 Drug Des Devel Ther pmid:21116336
Xu JW et al. Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. 2010 Appl. Microbiol. Biotechnol. pmid:19578843
Goldstone JV et al. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. 2010 BMC Genomics pmid:21087487
Mansfield BE et al. Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. 2010 PLoS Pathog. pmid:20941354
Liu XT et al. Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. 2010 Planta Med. pmid:19644795
Ottaviani M et al. Lipid mediators in acne. 2010 Mediators Inflamm. pmid:20871834
Liu J et al. Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria. 2010 Planta Med. pmid:19670160
LaFayette SL et al. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. 2010 PLoS Pathog. pmid:20865172
Ferreira C et al. Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p. 2010 BMC Microbiol. pmid:20843317
Fernandez-Arche A et al. Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. 2010 Phytomedicine pmid:19577446
Iskar M et al. Drug-induced regulation of target expression. 2010 PLoS Comput. Biol. pmid:20838579
Chung MJ et al. Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. 2010 Nutr Res Pract pmid:20607061
Zhu LW and Tang YJ Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides during the fermentation of Ganoderma lucidum. 2010 Bioprocess Biosyst Eng pmid:20369259
Yang XW et al. Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr. 2010 Org. Biomol. Chem. pmid:20372737
Al-Badriyeh D et al. Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. 2010 Clin Ophthalmol pmid:20463910
Jarvie E et al. Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. 2010 Clin. Sci. pmid:20443782
Kraus JM et al. Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. 2010 J. Med. Chem. pmid:20429511
Arendrup MC et al. Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence. 2010 PLoS ONE pmid:20404915
Chen CK et al. Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. 2010 PLoS Negl Trop Dis pmid:20386598
Choi SY et al. Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate. 2010 J. Biomed. Biotechnol. pmid:20300439
Solberg R et al. Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. 2010 PLoS ONE pmid:20231903
Carland F et al. The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products. 2010 Plant Physiol. pmid:20421456
Zhang ZD et al. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. 2010 Genome Biol. pmid:20210993
Batova M et al. Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). 2010 BMC Genomics pmid:20202201
Warrilow AG et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. 2010 Antimicrob. Agents Chemother. pmid:20660663
Epp E et al. Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. 2010 PLoS Pathog. pmid:20140196
Vazquez JA Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection. 2010 HIV AIDS (Auckl) pmid:22096388
Liang CX et al. Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. 2010 Appl. Microbiol. Biotechnol. pmid:20077112
Ianas V et al. Role of posaconazole in the treatment of oropharyngeal candidiasis. 2010 Infect Drug Resist pmid:21694893
Sharma A et al. Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice. 2010 Libyan J Med pmid:21483544
Lee I et al. Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells. 2010 J. Nat. Prod. pmid:20039640
Fon Tacer K et al. Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. 2010 J. Steroid Biochem. Mol. Biol. pmid:20206258
Che S et al. [RP-HPLC simultaneous determination of five triterpenoid acids in different parts of Poria cocos by UV wavelengths switch]. 2010 Yao Xue Xue Bao pmid:21355217
Wyder MA et al. Clearance in vivo of instilled [h]cholesterol from the rat lung. 2010 Biochem Res Int pmid:21188079
Ahmad A et al. Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. 2010 Microb. Pathog. pmid:19835945
Xu Y et al. Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. 2009 Respir. Res. pmid:19344509
Kitahama Y et al. The construction and characterization of self-sufficient lanosterol 14-demethylase fusion proteins consisting of yeast CYP51 and its reductase. 2009 Biol. Pharm. Bull. pmid:19336884
Pezacki JP et al. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. 2009 BMC Chem Biol pmid:19149867
Krueger KP and Nelson AC Economic considerations in the treatment of invasive aspergillosis: a review of voriconazole pharmacoeconomic studies. 2009 Clinicoecon Outcomes Res pmid:21935305
Desmond E and Gribaldo S Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature. 2009 Genome Biol Evol pmid:20333205
Godio RP and Martín JF Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. 2009 Fungal Genet. Biol. pmid:19130892
Sen K and Hackett JC Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis. 2009 J Phys Chem B pmid:19438188
Bureau C et al. Gene array analysis of adrenal glands in broiler chickens following ACTH treatment. 2009 BMC Genomics pmid:19751509
Sugai M et al. Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside. 2009 J Oleo Sci pmid:19145063
Chen CK et al. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. 2009 PLoS Negl Trop Dis pmid:19190730
Bozek K et al. Regulation of clock-controlled genes in mammals. 2009 PLoS ONE pmid:19287494
Sánchez-Wandelmer J et al. Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes. 2009 Biochim. Biophys. Acta pmid:19433058
Slominski AT et al. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. 2009 PLoS ONE pmid:19190754
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Nes WD et al. Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. 2009 Arch. Biochem. Biophys. pmid:19014901
Cheng SY et al. Revision of the absolute configuration at C(23) of lanostanoids and isolation of secondary metabolites from formosan soft coral Nephthea erecta. 2009 Chem. Biodivers. pmid:19180458
Morris TJ et al. Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits. 2009 PLoS ONE pmid:19787071
Zhang H et al. Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. 2009 Mol. Reprod. Dev. pmid:18937335
Sun LM et al. The effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans. 2009 Biol. Pharm. Bull. pmid:19122277
Ling H et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. 2009 Mol. Carcinog. pmid:18973184
Chen YJ et al. Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. 2009 Toxicol In Vitro pmid:19344682
Ohyama K et al. Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19139393
Akihisa T et al. Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. 2009 J. Nat. Prod. pmid:19746919
Yawata A et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. 2009 Eur J Pharm Sci pmid:19748575
Tang YJ et al. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. 2009 Bioresour. Technol. pmid:19010665
Ankam R et al. Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation. 2009 Indian J Pharm Sci pmid:20502575
Inada A et al. 24-Ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosana. 2009 Chem. Pharm. Bull. pmid:19881288
Adamec J et al. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds. 2009 J Sep Sci pmid:19937965
Dias JR and Gao H 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR. 2009 Spectrochim Acta A Mol Biomol Spectrosc pmid:19800838
Chen M et al. A new triterpene from the fruiting bodies of Ganoderma lucidum. 2009 Yao Xue Xue Bao pmid:19806918
King AR et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. 2009 Chem. Biol. pmid:19875078
Selmecki AM et al. Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. 2009 PLoS Genet. pmid:19876375
Queiroz R et al. Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. 2009 BMC Genomics pmid:19857263
Tavallaee M and Rad MM Fixed drug eruption resulting from fluconazole use: a case report. 2009 J Med Case Rep pmid:19830193
Kuehnle K et al. Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. 2009 Neurochem. Res. pmid:19115107
Liu J and Nes WD Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis. 2009 Molecules pmid:19924096
Boesze-Battaglia K et al. Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. 2009 J. Biol. Chem. pmid:19240023