MeSH term | MeSH ID | Detail |
---|---|---|
Abetalipoproteinemia | D000012 | 7 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Abetalipoproteinemia | D000012 | 7 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Van den Bossche H et al. | In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. | 1980 | Antimicrob. Agents Chemother. | pmid:6250469 |
Buurman ET et al. | Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds. | 2005 | Antimicrob. Agents Chemother. | pmid:15917573 |
Warrilow AG et al. | Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. | 2013 | Antimicrob. Agents Chemother. | pmid:23274672 |
Vanden Bossche H et al. | Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. | 1993 | Antimicrob. Agents Chemother. | pmid:8257130 |
Warrilow AG et al. | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. | 2010 | Antimicrob. Agents Chemother. | pmid:20660663 |
Price CL et al. | Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. | 2015 | Appl. Environ. Microbiol. | pmid:25746994 |
Parker JE et al. | Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. | 2011 | Appl. Environ. Microbiol. | pmid:21169436 |
Hajjaj H et al. | Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors. | 2005 | Appl. Environ. Microbiol. | pmid:16000773 |
Xu JW et al. | Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19578843 |
Zhao Z et al. | Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol. | 2011 | Appl. Microbiol. Biotechnol. | pmid:20809073 |