| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alvarez-Vasquez F et al. | Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. | 2011 | PLoS ONE | pmid:22194828 |
| Horvath SE et al. | Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae. | 2011 | Biochim. Biophys. Acta | pmid:21875690 |
| Keber R et al. | Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. | 2011 | J. Biol. Chem. | pmid:21705796 |
| Nowosielski M and Hoffmann M | Do the substituent effects affect conformational freedom of squalene in hopene biosynthesis? | 2011 | J Mol Model | pmid:21562825 |
| Sangshetti JN et al. | Synthesis, antifungal activity, and docking study of some new 1,2,4-triazole analogs. | 2011 | Chem Biol Drug Des | pmid:21752200 |
| Jiang Y et al. | Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21737273 |
| Sheng C et al. | Structure-based design, synthesis, and antifungal activity of new triazole derivatives. | 2011 | Chem Biol Drug Des | pmid:21585708 |
| Spitzer M et al. | Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. | 2011 | Mol. Syst. Biol. | pmid:21694716 |
| Alvarez-Rueda N et al. | Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance. | 2011 | PLoS ONE | pmid:21698128 |
| Baumann K et al. | Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. | 2011 | Microb. Cell Fact. | pmid:22050768 |
| Askarova S et al. | Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. | 2011 | Int J Alzheimers Dis | pmid:21547213 |
| Jiang J et al. | Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22033405 |
| Wang N et al. | N-Cyclo-propyl-N-[2-(2,4-difluoro-phen-yl)-2-hy-droxy-1-(1H-1,2,4-triazol-1-yl)prop-yl]-2-(5-methyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)acetamide dichloro-methane 0.62-solvate. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22059025 |
| Wang Z et al. | Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids. | 2011 | Plant Physiol. | pmid:21059824 |
| Idkowiak J et al. | Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21190981 |
| Chauvigné F et al. | Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. | 2011 | PLoS ONE | pmid:22087261 |
| Elias PM et al. | Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders. | 2011 | Dermatoendocrinol | pmid:21695019 |
| Liu Y et al. | Sensitive and selective liquid chromatography-tandem mass spectrometry method for the determination of five ganoderic acids in Ganoderma lucidum and its related species. | 2011 | J Pharm Biomed Anal | pmid:21130592 |
| Zhang XQ et al. | Triterpenoids with neurotrophic activity from Ganoderma lucidum. | 2011 | Nat. Prod. Res. | pmid:21671206 |
| Park HG et al. | Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans. | 2011 | Arch. Biochem. Biophys. | pmid:21315684 |
| Ito R et al. | Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases. | 2011 | Org. Lett. | pmid:21526825 |
| Oliaro-Bosso S et al. | Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. | 2011 | PLoS ONE | pmid:21811565 |
| Burkhardt R et al. | Cosegregation of aortic root atherosclerosis and intermediate lipid phenotypes on chromosomes 2 and 8 in an intercross of C57BL/6 and BALBc/ByJ low-density lipoprotein receptor-/- mice. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21252064 |
| Jedinak A et al. | Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling. | 2011 | Int. J. Oncol. | pmid:21225227 |
| Rosa Ide A et al. | Ultrastructural alterations induced by Δ(24(25))-sterol methyltransferase inhibitors on Trichomonas vaginalis. | 2011 | FEMS Microbiol. Lett. | pmid:21175744 |
| Wu TK et al. | Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17α/β-exocyclic side chain stereochemistry. | 2011 | Org. Biomol. Chem. | pmid:21157613 |
| Tripodi KE et al. | Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. | 2011 | Enzyme Res | pmid:21603276 |
| Oh HG et al. | Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles. | 2011 | Lab Anim Res | pmid:22232635 |
| Lou HY et al. | Hepatic failure related to itraconazole use successfully treated by corticosteroids. | 2011 | Hepat Mon | pmid:22224084 |
| Semighini CP et al. | Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. | 2011 | PLoS Pathog. | pmid:22114551 |
| Acimovic J et al. | Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis. | 2011 | Drug Metab. Dispos. | pmid:20952551 |
| Cabrito TR et al. | The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. | 2011 | Biochem. J. | pmid:21831043 |
| Chadwick W et al. | Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. | 2011 | PLoS ONE | pmid:21738745 |
| Mullins JG et al. | Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola. | 2011 | PLoS ONE | pmid:21738598 |
| Lat A and Thompson GR | Update on the optimal use of voriconazole for invasive fungal infections. | 2011 | Infect Drug Resist | pmid:21694908 |
| Singh A and Prasad R | Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. | 2011 | PLoS ONE | pmid:21559392 |
| Mayr A and Lass-Flörl C | Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. | 2011 | Eur. J. Med. Res. | pmid:21486729 |
| Sandherr M and Maschmeyer G | Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature. | 2011 | Eur. J. Med. Res. | pmid:21486727 |
| Vargas FA et al. | Expanding a dynamic flux balance model of yeast fermentation to genome-scale. | 2011 | BMC Syst Biol | pmid:21595919 |
| Choi MH et al. | Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma. | 2011 | BMC Cancer | pmid:21824401 |
| Kim D et al. | Functional expression and characterization of CYP51 from dandruff-causing Malassezia globosa. | 2011 | FEMS Yeast Res. | pmid:21114623 |
| Leichner GS et al. | Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. | 2011 | J. Biol. Chem. | pmid:21778231 |
| Dutra RC et al. | Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. | 2011 | PLoS ONE | pmid:22073270 |
| Koturbash I et al. | Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. | 2011 | Environ. Health Perspect. | pmid:21147608 |
| Chen NH and Zhong JJ | p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. | 2011 | Phytomedicine | pmid:21353507 |
| Zhong XH et al. | Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549. | 2011 | Chin J Integr Med | pmid:21359924 |
| Paller AS et al. | Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism. | 2011 | J. Invest. Dermatol. | pmid:21753784 |
| Kennedy EM et al. | Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. | 2011 | J. Nat. Prod. | pmid:22044278 |
| Sang ZG et al. | [Studies on the secondary metabolites of Coriolopsis sp. G066]. | 2011 | Zhong Yao Cai | pmid:21809540 |
| Zhao Z et al. | Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol. | 2011 | Appl. Microbiol. Biotechnol. | pmid:20809073 |