| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aoyama Y et al. | 7-Oxo-24,25-dihydrolanosterol: a novel lanosterol 14 alpha-demethylase (P-45014DM) inhibitor which blocks electron transfer to the oxyferro intermediate. | 1987 | Biochim. Biophys. Acta | pmid:3318933 |
| Rodriguez RJ et al. | Multiple functions for sterols in Saccharomyces cerevisiae. | 1985 | Biochim. Biophys. Acta | pmid:3904834 |
| Yeagle PL | Lanosterol and cholesterol have different effects on phospholipid acyl chain ordering. | 1985 | Biochim. Biophys. Acta | pmid:3986200 |
| Bojesen E et al. | Sterol biosynthesis in vitro of rat renal inner medulla. | 1973 | Biochim. Biophys. Acta | pmid:4713153 |
| Aoyama Y et al. | Structural analysis of the interaction between the side-chain of substrates and the active site of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast. | 1992 | Biochim. Biophys. Acta | pmid:1504086 |
| Kim CK et al. | Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase. | 1995 | Biochim. Biophys. Acta | pmid:7492613 |
| Su CY et al. | Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen. | 1999 | Biochim. Biophys. Acta | pmid:10064905 |
| Ott RG et al. | Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p. | 2005 | Biochim. Biophys. Acta | pmid:15951236 |
| Mo C et al. | In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. | 2003 | Biochim. Biophys. Acta | pmid:12842197 |
| Aoyama Y et al. | Involvement of cytochrome b5 and a cyanide-sensitive monooxygenase in the 4-demethylation of 4,4-dimethylzymosterol by yeast microsomes. | 1981 | Biochim. Biophys. Acta | pmid:6163470 |
| Aoyama Y et al. | Evidence for the presence of cytochrome P-450 functional in lanosterol 14 alpha-demethylation in microsomes of aerobically grown respiring yeast. | 1981 | Biochim. Biophys. Acta | pmid:6170339 |
| Leoni V and Caccia C | The impairment of cholesterol metabolism in Huntington disease. | 2015 | Biochim. Biophys. Acta | pmid:25596342 |
| Sonoda Y et al. | Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation. | 1993 | Biochim. Biophys. Acta | pmid:8399332 |
| Suárez Y et al. | Sterol stringency of proliferation and cell cycle progression in human cells. | 2005 | Biochim. Biophys. Acta | pmid:15904877 |
| Urbina JA et al. | Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7548131 |
| Moroyama T et al. | Changes in sterol metabolism in the skin of developing chick embryo and alterations in the presence of an anticholesterolemic agent and a chemical carcinogen. | 1982 | Biochim. Biophys. Acta | pmid:6812647 |
| Kawaguchi A et al. | Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. | 1973 | Biochim. Biophys. Acta | pmid:4120185 |
| Rahier A and Taton M | Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14 alpha-demethylase. | 1992 | Biochim. Biophys. Acta | pmid:1571366 |
| Pereira M et al. | Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis. | 2010 | Biochim. Biophys. Acta | pmid:20624480 |
| Thompson ED et al. | Identification and properties of a sterol-binding polysaccharide isolated from Saccharomyces cerevisiae. | 1973 | Biochim. Biophys. Acta | pmid:4573201 |