MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zheng WF et al. | Sterol composition in field-grown and cultured mycelia of Inonotus obliquus. | 2007 | Yao Xue Xue Bao | pmid:17882960 |
Arneborg N et al. | The effect of ethanol and specific growth rate on the lipid content and composition of Saccharomyces cerevisiae grown anaerobically in a chemostat. | 1995 | Yeast | pmid:8533470 |
Weber JM et al. | Factors affecting homologous overexpression of the Saccharomyces cerevisiae lanosterol 14 alpha-demethylase gene. | 1992 | Yeast | pmid:1523885 |
Berg D et al. | The effect of clotrimazole and triadimefon on 3-hydroxy-3-methyl-glutaryl-CoA-reductase-[EC 1.1.1.34]-activity in Saccharomyces cerevisiae. | 1981 Sep-Oct | Z. Naturforsch., C, Biosci. | pmid:7029940 |
Ma BJ and Ruan Y | Trametes versatillis, a fungus highly producing eburicoic acid. | 2007 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:18274297 |
Cantillo-Ciau Z et al. | Two new 24-isopropenyl-lanostanoids from Tillandsia brachycaulos. | 2003 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:14577625 |
Zhang XQ et al. | [Chemical constituents of the spores of Ganoderma lucidum]. | 2008 | Zhong Yao Cai | pmid:18589746 |
Sang ZG et al. | [Studies on the secondary metabolites of Coriolopsis sp. G066]. | 2011 | Zhong Yao Cai | pmid:21809540 |
Gao JC et al. | [Study on chemical constituents from rhizomes of Actaea asiatica]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309667 |
Zhang Y et al. | [Dynamic accumulation of three main triterpenic acids in submerged cultivation mycelium of Poria cocos]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23944068 |