| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dahl CE et al. | Effects of cycloartenol and lanosterol on artificial and natural membranes. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7356454 |
| Beach DH et al. | Effects of ketoconazole on sterol biosynthesis by Trypanosoma cruzi epimastigotes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3521598 |
| Pinkerton FD et al. | Inhibitors of sterol synthesis. 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol induces changes in the sterol composition and the morphology of CHO-K1 cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3196343 |
| Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
| Gibbons GF et al. | Lanosterol 14alpha-demethylase. The metabolism of some potential intermediates by cell-free systems from rat liver. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1267815 |
| Johnson RC and Shah SN | Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. | 1973 | Biochem. Biophys. Res. Commun. | pmid:4741538 |
| Cabello-Hurtado F et al. | Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016788 |
| Ohba M et al. | Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:369554 |
| Taylor FR and Parks LW | Adaptation of Saccharomyces cerevisiae to growth on cholesterol: selection of mutants defective in the formation of lanosterol. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6998481 |
| Buttke TM and Van Cleave S | Adaptation of a cholesterol deficient human T cell line to growth with lanosterol. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8166689 |
| Seliskar M et al. | Expression of microsomal lanosterol 14alpha-demethylase (CYP51) in an engineered soluble monomeric form. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18466759 |
| Bard M et al. | Characterization of a cytochrome P450 deficient mutant of Candida albicans. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307785 |
| Revankar SG et al. | Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474487 |
| Wiss O and Wiss V | The degradation of labelled lanosterol by homogenate of rat liver: evidence for the formation of lithocholic acid from lanosterol without cholesterol as intermediate. | 1978 | Biochem. Biophys. Res. Commun. | pmid:708435 |
| Aoyama Y and Yoshida Y | The 14alpha-demethylation of lanosterol by a reconstituted cytochrome P-450 system from yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:105731 |
| Kushiro M et al. | Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11437378 |
| Jackson CJ et al. | Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565899 |
| Buttke TM and Bloch K | Comparative responses of the yeast mutant strain GL7 to lanosterol, cycloartenol, and cyclolaudenol. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6986865 |
| Nes WD et al. | Regulation of sterol biosynthesis in sunflower by 24(R,S),25-epiminolanosterol, a novel C-24 methyl transferase inhibitor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2043140 |
| M'Baya B and Karst F | In vitro assay of squalene epoxidase of Saccharomyces cerevisiae. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3307781 |
| Emmons GT et al. | 20,25-Diazacholesterol, clofibric acid and 2,4-dichlorophenoxyacetic acid--all inducers of myotonia--perturb the post-lanosterol sector of sterol biosynthesis in cultured chick embryo fibroblasts. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437038 |
| Boutaud O et al. | Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7887959 |
| Ortiz de Montellano PR et al. | Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. | 1979 | Biochem. Biophys. Res. Commun. | pmid:508352 |
| Baila-Rueda L et al. | Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406166 |
| Aoyama Y et al. | Buthiobate: a potent inhibitor for yeast cytochrome P-450 catalyzing 14 alpha-demethylation of lanosterol. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6414474 |
| Aoyama Y and Yoshida Y | Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872829 |
| Tabacik C et al. | Post-HMG CoA reductase regulation of cholesterol biosynthesis in normal human lymphocytes : lanosten-3 betal-ol-32-al, a natural inhibitor. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306125 |
| Aoyama Y and Yoshida Y | Evidence for the contribution of a sterol 14-reductase to the 14 alpha-demethylation of lanosterol by yeast. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418830 |
| Nes WD et al. | Control of fungal sterol C-24 transalkylation: importance to developmental regulation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3767970 |
| Yoshida Y et al. | Spectral properties of a novel cytochrome P-450 of a Saccharomyces cerevisiae mutant SG1. A cytochrome P-450 species having a nitrogenous ligand trans to thiolate. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3884012 |
| Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
| Gibbons FG et al. | Studies on the mechanism of lanosterol 14 alpha-demethylation. A requirement for two distinct types of mixed-function-oxidase systems. | 1979 | Biochem. J. | pmid:534498 |
| Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
| Iglesias J and Gibbons GF | Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol. | 1989 | Biochem. J. | pmid:2604729 |
| Lamb DC et al. | Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family. | 2002 | Biochem. J. | pmid:12023899 |
| Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
| MARCUS S | Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr. | 1952 | Biochem. J. | pmid:14925127 |
| Azrolan NI and Coleman PS | A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system. | 1989 | Biochem. J. | pmid:2705993 |
| Hitchcock CA et al. | Purification and properties of cytochrome P-450-dependent 14 alpha-sterol demethylase from Candida albicans. | 1989 | Biochem. J. | pmid:2556999 |
| Gibbons GF and Mitropoulos KA | The effect of carbon monoxide on the nature of the accumulated 4,4-dimethyl sterol precursors of cholesterol during its biosynthesis from (2-14C)mevalonic acid in vitro. | 1973 | Biochem. J. | pmid:4724584 |
| Gibbons GF and Mitropoulos KA | Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. | 1972 | Biochem. J. | pmid:5073750 |
| Wojciechowski ZA et al. | S-adenosyl-L-methionine-cycloartenol methyltransferase activity in cell-free systems from Trebouxia sp. and Scenedesmus obliquus. | 1973 | Biochem. J. | pmid:4774402 |
| Willett JD and Downey WL | Sterol biosynthesis in the free-living nematode Panagrellus redivivus. | 1974 | Biochem. J. | pmid:4822732 |
| Patkar P et al. | C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications. | 2013 | Biochem. J. | pmid:23984880 |
| Beastall GH et al. | Studies on phytosterol biosynthesis: metabolism of 24,25-dihydrolanosterol and cholesterol in Ochromonas malhamensis. | 1972 | Biochem. J. | pmid:5085559 |
| Nes CR et al. | Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. | 2012 | Biochem. J. | pmid:22176028 |
| Cabrito TR et al. | The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. | 2011 | Biochem. J. | pmid:21831043 |
| Bae SH and Paik YK | Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | 1997 | Biochem. J. | pmid:9291139 |
| Wang CN et al. | The inhibition of human platelet function by ganodermic acids. | 1991 | Biochem. J. | pmid:1649599 |
| Derksen A et al. | Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. | 1976 | Biochem. J. | pmid:822845 |