| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fassbender K et al. | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. | 2008 | Atherosclerosis | pmid:17137582 |
| Martirosyan DM et al. | Amaranth oil application for coronary heart disease and hypertension. | 2007 | Lipids Health Dis | pmid:17207282 |
| Cournia Z et al. | Differential effects of cholesterol, ergosterol and lanosterol on a dipalmitoyl phosphatidylcholine membrane: a molecular dynamics simulation study. | 2007 | J Phys Chem B | pmid:17261058 |
| Han QB et al. | Preparative isolation of cyclolanostane-type saponins from Astragalus membranaceus bge. var. mongholicus (Bge.) Hsiao by TLC-MS/MS guided high-speed counter-current chromatography. | 2007 | J Sep Sci | pmid:17313153 |
| Haba H et al. | Diterpenoids and triterpenoids from Euphorbia guyoniana. | 2007 | Phytochemistry | pmid:17337022 |
| Sandström MC et al. | Structure of mixed micelles formed in PEG-lipid/lipid dispersions. | 2007 | Langmuir | pmid:17343401 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Li L and Porter TD | Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase. | 2007 | Arch. Biochem. Biophys. | pmid:17374357 |
| Shumyantseva VV et al. | Electrochemical properties of cytochroms P450 using nanostructured electrodes: direct electron transfer and electro catalysis. | 2007 | J. Inorg. Biochem. | pmid:17376532 |
| Lu B et al. | Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. | 2007 | Anal. Chim. Acta | pmid:17386793 |
| Parish EJ et al. | Syntheses of ring C oxysterols: inhibitors of sterol biosynthesis. | 2007 | Lipids | pmid:17393208 |
| Wong J et al. | Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | 2007 | Lipids Health Dis | pmid:17408498 |
| Sánchez-MartÃn CC et al. | Cholesterol starvation induces differentiation of human leukemia HL-60 cells. | 2007 | Cancer Res. | pmid:17409448 |
| Bastos KP et al. | The transcriptome analysis of early morphogenesis in Paracoccidioides brasiliensis mycelium reveals novel and induced genes potentially associated to the dimorphic process. | 2007 | BMC Microbiol. | pmid:17425801 |
| Chong CR et al. | Inhibition of angiogenesis by the antifungal drug itraconazole. | 2007 | ACS Chem. Biol. | pmid:17432820 |
| Hubbert ML et al. | Regulation of hepatic Insig-2 by the farnesoid X receptor. | 2007 | Mol. Endocrinol. | pmid:17440045 |
| Wang G et al. | Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. | 2007 | Int. Immunopharmacol. | pmid:17466920 |
| Cushion MT et al. | Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. | 2007 | PLoS ONE | pmid:17487271 |
| Thomas JH | Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. | 2007 | PLoS Genet. | pmid:17500592 |
| Guillemette T et al. | Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger. | 2007 | BMC Genomics | pmid:17561995 |
| Lamb DC et al. | Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. | 2007 | Mol. Biol. Evol. | pmid:17567593 |
| Cai SY et al. | The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17567710 |
| Lepesheva GI et al. | Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. | 2007 | Arch. Biochem. Biophys. | pmid:17585868 |
| Hughes AL et al. | 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. | 2007 | J. Biol. Chem. | pmid:17595166 |
| Shumyantseva VV et al. | Electrochemical reduction of sterol-14alpha-demethylase from Mycobacterium tuberculosis (CYP51b1). | 2007 | Biochemistry Mosc. | pmid:17630911 |
| Nguyen AD et al. | Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. | 2007 | J. Biol. Chem. | pmid:17635920 |
| Zhao QJ et al. | Design, synthesis, and antifungal activities of novel 1H-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (CYP51). | 2007 | Chem. Biodivers. | pmid:17638327 |
| Guan SH et al. | Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Delta(16, 17) double bond from Ganoderma lucidum. | 2007 | Magn Reson Chem | pmid:17640004 |
| Stojakovic T et al. | Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid. | 2007 | Hepatology | pmid:17668874 |
| Valenza M et al. | Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease. | 2007 | Neurobiol. Dis. | pmid:17702587 |
| Zheng WF et al. | Sterol composition in field-grown and cultured mycelia of Inonotus obliquus. | 2007 | Yao Xue Xue Bao | pmid:17882960 |
| Chen Q et al. | Biosynthesis of phytosterol esters: identification of a sterol o-acyltransferase in Arabidopsis. | 2007 | Plant Physiol. | pmid:17885082 |
| Yao B et al. | Synthesis and antifungal activities of novel 2-aminotetralin derivatives. | 2007 | J. Med. Chem. | pmid:17900179 |
| Villagra A et al. | Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. | 2007 | J. Biol. Chem. | pmid:17925399 |
| Nakano C et al. | Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928701 |
| Oliver BG et al. | cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p. | 2007 | Eukaryotic Cell | pmid:17951521 |
| Korosec T et al. | Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51). | 2008 | Bioorg. Med. Chem. | pmid:17964172 |
| Moe M et al. | Gene expression profiles in testis of pigs with extreme high and low levels of androstenone. | 2007 | BMC Genomics | pmid:17988377 |
| Lange Y et al. | Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. | 2008 | J. Biol. Chem. | pmid:18024962 |
| Wang N et al. | ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. | 2008 | FASEB J. | pmid:18039927 |
| Javitt NB | Oxysterols: novel biologic roles for the 21st century. | 2008 | Steroids | pmid:18068744 |
| Wilcox CB et al. | Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. | 2007 | BMC Cancer | pmid:18070364 |
| Godio RP et al. | A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium. | 2007 | Chem. Biol. | pmid:18096502 |
| DOREE C et al. | Position of the hydroxyl group in lanosterol. | 1949 | Nature | pmid:18107580 |
| Eapen BR | Photosensitivity in Smith-Lemli-Opitz syndrome: a flux balance analysis of altered metabolism. | 2007 | Bioinformation | pmid:18188427 |
| Bizerra FC et al. | Characteristics of biofilm formation by Candida tropicalis and antifungal resistance. | 2008 | FEMS Yeast Res. | pmid:18248413 |
| Li H et al. | Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis. | 2008 | J. Nat. Prod. | pmid:18271558 |
| Ma BJ and Ruan Y | Trametes versatillis, a fungus highly producing eburicoic acid. | 2007 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:18274297 |
| Gao JC et al. | [Study on chemical constituents from rhizomes of Actaea asiatica]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309667 |
| Sood R and Kinnunen PK | Cholesterol, lanosterol, and ergosterol attenuate the membrane association of LL-37(W27F) and temporin L. | 2008 | Biochim. Biophys. Acta | pmid:18358828 |
| Pemán J et al. | Voriconazole in the management of nosocomial invasive fungal infections. | 2006 | Ther Clin Risk Manag | pmid:18360588 |
| Andersen MR et al. | Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. | 2008 | Mol. Syst. Biol. | pmid:18364712 |
| Gao HY et al. | Novel lanostane and rearranged lanostane-type triterpenoids from Abies sachalinensis - II -. | 2008 | Chem. Pharm. Bull. | pmid:18379107 |
| Jiang J et al. | Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. | 2008 | Int. J. Mol. Med. | pmid:18425349 |
| Seliskar M et al. | Expression of microsomal lanosterol 14alpha-demethylase (CYP51) in an engineered soluble monomeric form. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18466759 |
| Ning G et al. | 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. | 2008 | Mol. Endocrinol. | pmid:18467523 |
| Wright GD and Honek JF | Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222. | 1991 | J. Bacteriol. | pmid:1846852 |
| Vazquez JA | Role of posaconazole in the management of oropharyngeal and esophageal candidiasis. | 2007 | Ther Clin Risk Manag | pmid:18472974 |
| Winne JM et al. | Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring. | 2008 | Org. Biomol. Chem. | pmid:18480904 |
| Wang N et al. | Lanostane-type triterpenoids from the roots of Kadsura coccinea. | 2008 | J. Nat. Prod. | pmid:18491866 |
| Mueller AM et al. | Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. | 2008 | J Neuroinflammation | pmid:18501024 |
| Sabatini K et al. | Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC. | 2008 | Biophys. J. | pmid:18515391 |
| Xu B et al. | Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA. | 2008 | Biol. Pharm. Bull. | pmid:18520052 |
| El Dine RS et al. | Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum. | 2008 | J. Nat. Prod. | pmid:18547117 |
| Whitson EL et al. | Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. | 2008 | J. Nat. Prod. | pmid:18558742 |
| Li X et al. | Multiple effects of a novel compound from Burkholderia cepacia against Candida albicans. | 2008 | FEMS Microbiol. Lett. | pmid:18565124 |
| Wang J and Wu J | Antifungal activity of 25-azalanosterol against Candida species. | 2008 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:18574605 |
| Zhang XQ et al. | [Chemical constituents of the spores of Ganoderma lucidum]. | 2008 | Zhong Yao Cai | pmid:18589746 |
| Burgess B et al. | Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18599800 |
| Paik MJ et al. | Gas chromatographic-mass spectrometric analyses of cholesterol and its precursors in rat plasma as tert-butyldimethylsilyl derivatives. | 2008 | Clin. Chim. Acta | pmid:18657530 |
| Wang Y et al. | Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha. | 2008 | J. Biol. Chem. | pmid:18676367 |
| Vinci G et al. | Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. | 2008 | PLoS ONE | pmid:18682733 |
| Parker JE et al. | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. | 2008 | Antimicrob. Agents Chemother. | pmid:18694951 |
| Nes WD et al. | Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase. | 1991 | J. Biol. Chem. | pmid:1869550 |
| Aoyama Y and Yoshida Y | Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872829 |
| Freilich S et al. | Metabolic innovations towards the human lineage. | 2008 | BMC Evol. Biol. | pmid:18782449 |
| Bennati AM et al. | Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. | 2008 | FEBS J. | pmid:18785926 |
| Abrahamsson H et al. | Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation. | 2008 | Scand. J. Gastroenterol. | pmid:18788050 |
| Zhou L et al. | Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. | 2008 | Chem. Pharm. Bull. | pmid:18827390 |
| Wu TK et al. | Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions. | 2008 | Org. Lett. | pmid:18842050 |
| DOREE C et al. | Lanosterol; hydrocarbons formed by the action of dehydrating agents. | 1947 | J Chem Soc | pmid:18920806 |
| Neubauer H et al. | Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. | 2008 | Breast Cancer Res. | pmid:18922159 |
| Zhang H et al. | Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. | 2009 | Mol. Reprod. Dev. | pmid:18937335 |
| de Sain-van der Velden MG et al. | Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. | 2008 | J. Inherit. Metab. Dis. | pmid:18949577 |
| Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
| Monostory K et al. | Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent. | 2009 | Drug Metab. Dispos. | pmid:18971317 |
| Ling H et al. | Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. | 2009 | Mol. Carcinog. | pmid:18973184 |
| Willger SD et al. | A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. | 2008 | PLoS Pathog. | pmid:18989462 |
| Tamboli IY et al. | Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. | 2008 | J. Neurosci. | pmid:19005074 |
| Song X et al. | Expression and regulation of lanosterol 14alpha-demethylase in mouse embryo and uterus during the peri-implantation period. | 2008 | Reprod. Fertil. Dev. | pmid:19007561 |
| Tang YJ et al. | Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. | 2009 | Bioresour. Technol. | pmid:19010665 |
| Bhasker CR and Friedmann T | Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. | 2008 | BMC Genomics | pmid:19014463 |
| Nes WD et al. | Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. | 2009 | Arch. Biochem. Biophys. | pmid:19014901 |
| Kervizic G and Corcos L | Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. | 2008 | BMC Syst Biol | pmid:19025648 |
| Nomura M et al. | Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. | 2008 Sep-Oct | Anticancer Res. | pmid:19035296 |
| Mosig S et al. | Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. | 2008 | BMC Med Genomics | pmid:19040724 |
| Stanikunaite R et al. | Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity. | 2008 | J. Nat. Prod. | pmid:19067555 |
| Sun B et al. | Two novel A-seco-rearranged lanostane triterpenoids from Abies sachalinensis. | 2008 | Arch. Pharm. Res. | pmid:19099219 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Sun LM et al. | The effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans. | 2009 | Biol. Pharm. Bull. | pmid:19122277 |