MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Martinez-Seara H et al. | Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes. | 2010 | PLoS ONE | pmid:20567600 |
Jeschke MG et al. | The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes. | 2012 | PLoS ONE | pmid:22606232 |
Brumfield KM et al. | Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. | 2010 | PLoS ONE | pmid:20084111 |
Chiba T et al. | Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. | 2014 | PLoS ONE | pmid:25551765 |
Vinci G et al. | Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. | 2008 | PLoS ONE | pmid:18682733 |
Chauvigné F et al. | Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. | 2011 | PLoS ONE | pmid:22087261 |
Bozek K et al. | Regulation of clock-controlled genes in mammals. | 2009 | PLoS ONE | pmid:19287494 |
Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |
Gas-Pascual E et al. | Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. | 2014 | PLoS ONE | pmid:25343375 |
Vallejo MC et al. | Lipidomic analysis of extracellular vesicles from the pathogenic phase of Paracoccidioides brasiliensis. | 2012 | PLoS ONE | pmid:22745761 |
Hartwig T et al. | Propiconazole is a specific and accessible brassinosteroid (BR) biosynthesis inhibitor for Arabidopsis and maize. | 2012 | PLoS ONE | pmid:22590578 |
Tebbets B et al. | Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. | 2012 | PLoS ONE | pmid:22574132 |
Riccombeni A et al. | Sequence and analysis of the genome of the pathogenic yeast Candida orthopsilosis. | 2012 | PLoS ONE | pmid:22563396 |
Straud S et al. | Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. | 2010 | PLoS ONE | pmid:20661293 |
Wang X et al. | Genome-wide linkage scan of a pedigree with familial hypercholesterolemia suggests susceptibility loci on chromosomes 3q25-26 and 21q22. | 2011 | PLoS ONE | pmid:22022364 |
Singh A and Prasad R | Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. | 2011 | PLoS ONE | pmid:21559392 |
Guan W et al. | Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen. | 2010 | PLoS ONE | pmid:20593017 |
Dutra RC et al. | Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. | 2011 | PLoS ONE | pmid:22073270 |
Kaddurah-Daouk R et al. | Enteric microbiome metabolites correlate with response to simvastatin treatment. | 2011 | PLoS ONE | pmid:22022402 |