MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Targett-Adams P et al. | Lipid metabolism and HCV infection. | 2010 | Viruses | pmid:21994676 |
Wang FS et al. | [Studies on the ganoderic acid, a new constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst]. | 1997 | Yao Xue Xue Bao | pmid:11596326 |
Zheng WF et al. | Sterol composition in field-grown and cultured mycelia of Inonotus obliquus. | 2007 | Yao Xue Xue Bao | pmid:17882960 |
Zhao FQ et al. | [Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4]. | 2012 | Yao Xue Xue Bao | pmid:22812017 |
Luo J and Lin ZB | [A new triterpene from the fruiting bodies of Ganoderma lucidum]. | 2001 | Yao Xue Xue Bao | pmid:12579936 |
Xie LR et al. | [A new 3, 4-seco-lanostane triterpenoid from a marine-derived fungus Ascotricha sp. ZJ-M-5]. | 2013 | Yao Xue Xue Bao | pmid:23600147 |
Zhu ZJ et al. | [Studies on the active constituents of Momordica charantia L]. | 1990 | Yao Xue Xue Bao | pmid:2104468 |
Chen RY and Yu DQ | [Progress of studies on the chemical constituents of Ganoderma triterpene]. | 1990 | Yao Xue Xue Bao | pmid:2104477 |
Chen RY and Yu DQ | [Studies on the triterpenoid constituents of the spores from Ganoderma lucidum karst]. | 1991 | Yao Xue Xue Bao | pmid:1957672 |
Chen M et al. | A new triterpene from the fruiting bodies of Ganoderma lucidum. | 2009 | Yao Xue Xue Bao | pmid:19806918 |
Che S et al. | [RP-HPLC simultaneous determination of five triterpenoid acids in different parts of Poria cocos by UV wavelengths switch]. | 2010 | Yao Xue Xue Bao | pmid:21355217 |
Arneborg N et al. | The effect of ethanol and specific growth rate on the lipid content and composition of Saccharomyces cerevisiae grown anaerobically in a chemostat. | 1995 | Yeast | pmid:8533470 |
Weber JM et al. | Factors affecting homologous overexpression of the Saccharomyces cerevisiae lanosterol 14 alpha-demethylase gene. | 1992 | Yeast | pmid:1523885 |
Berg D et al. | The effect of clotrimazole and triadimefon on 3-hydroxy-3-methyl-glutaryl-CoA-reductase-[EC 1.1.1.34]-activity in Saccharomyces cerevisiae. | 1981 Sep-Oct | Z. Naturforsch., C, Biosci. | pmid:7029940 |
Ma BJ and Ruan Y | Trametes versatillis, a fungus highly producing eburicoic acid. | 2007 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:18274297 |
Cantillo-Ciau Z et al. | Two new 24-isopropenyl-lanostanoids from Tillandsia brachycaulos. | 2003 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:14577625 |
Zhang XQ et al. | [Chemical constituents of the spores of Ganoderma lucidum]. | 2008 | Zhong Yao Cai | pmid:18589746 |
Sang ZG et al. | [Studies on the secondary metabolites of Coriolopsis sp. G066]. | 2011 | Zhong Yao Cai | pmid:21809540 |
Zhao XH et al. | [Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015286 |
Pan RL et al. | [Studies on the new triterpenoid saponin of the aerial part of Cimicifuga foetida]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015306 |