| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dahl CE et al. | Effects of cycloartenol and lanosterol on artificial and natural membranes. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7356454 |
| Pinkerton FD et al. | Inhibitors of sterol synthesis. 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol induces changes in the sterol composition and the morphology of CHO-K1 cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3196343 |
| Seliskar M et al. | Expression of microsomal lanosterol 14alpha-demethylase (CYP51) in an engineered soluble monomeric form. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18466759 |
| Revankar SG et al. | Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474487 |
| Wiss O and Wiss V | The degradation of labelled lanosterol by homogenate of rat liver: evidence for the formation of lithocholic acid from lanosterol without cholesterol as intermediate. | 1978 | Biochem. Biophys. Res. Commun. | pmid:708435 |
| Aoyama Y and Yoshida Y | Interaction of lanosterol to cytochrome P-450 purified from yeast microscomes: evidence for contribution of cytochrome P-450 to lanosterol metabolism. | 1978 | Biochem. Biophys. Res. Commun. | pmid:27189 |
| Aoyama Y and Yoshida Y | The 14alpha-demethylation of lanosterol by a reconstituted cytochrome P-450 system from yeast microsomes. | 1978 | Biochem. Biophys. Res. Commun. | pmid:105731 |
| Buttke TM and Bloch K | Comparative responses of the yeast mutant strain GL7 to lanosterol, cycloartenol, and cyclolaudenol. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6986865 |
| Ortiz de Montellano PR et al. | Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols. | 1979 | Biochem. Biophys. Res. Commun. | pmid:508352 |
| Maitra US et al. | Purification of a terminal oxygenase in demethylation of C-30 of lanosterol. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6816234 |
| Polo MP and de Bravo MG | Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | 2006 | Biochem. Cell Biol. | pmid:16462894 |
| Tavares IA et al. | 4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol. | 1977 | Biochem. J. | pmid:20077 |
| Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
| Malvoisin E et al. | Relationship between membrane sterol composition and responsiveness to 12-O-tetradecanoylphorbol 13-acetate in HL-60 human promyelocytic leukaemia cell lines. | 1988 | Biochem. J. | pmid:3162674 |
| Wojciechowski ZA et al. | S-adenosyl-L-methionine-cycloartenol methyltransferase activity in cell-free systems from Trebouxia sp. and Scenedesmus obliquus. | 1973 | Biochem. J. | pmid:4774402 |
| Bae S et al. | Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. | 2001 | Biochem. J. | pmid:11171067 |
| Marco de la Calle C et al. | A relationship between the activities of hepatic lanosterol 14 alpha-demethylase and 3-hydroxy-3-methylglutaryl-CoA reductase. | 1988 | Biochem. J. | pmid:3355520 |
| Cabrito TR et al. | The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. | 2011 | Biochem. J. | pmid:21831043 |
| Tavares IA et al. | The pathway for the conversion of dihydroagnosterol into cholesterol in rat liver. | 1977 | Biochem. J. | pmid:901410 |
| Derksen A et al. | Non-human primate platelets and arterial tissue cannot convert preformed [14C]lanosterol into[14C]cholesterol in vivo. | 1976 | Biochem. J. | pmid:822845 |