| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gleason JE et al. | Analysis of hypoxia and hypoxia-like states through metabolite profiling. | 2011 | PLoS ONE | pmid:21931840 |
| Cantu D et al. | Next generation sequencing provides rapid access to the genome of Puccinia striiformis f. sp. tritici, the causal agent of wheat stripe rust. | 2011 | PLoS ONE | pmid:21909385 |
| Slominski AT et al. | Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. | 2009 | PLoS ONE | pmid:19190754 |
| Valdes VJ et al. | CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. | 2012 | PLoS ONE | pmid:22479487 |
| Ngamskulrungroj P et al. | Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. | 2012 | PLoS ONE | pmid:22412978 |
| Desnos-Ollivier M et al. | Antifungal susceptibility profiles of 1698 yeast reference strains revealing potential emerging human pathogens. | 2012 | PLoS ONE | pmid:22396754 |
| Snelders E et al. | Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. | 2012 | PLoS ONE | pmid:22396740 |
| Morris TJ et al. | Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits. | 2009 | PLoS ONE | pmid:19787071 |
| Takami T et al. | A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. | 2012 | PLoS ONE | pmid:23145048 |
| Weete JD et al. | Phylogenetic distribution of fungal sterols. | 2010 | PLoS ONE | pmid:20526375 |
| Chen CK et al. | Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. | 2009 | PLoS Negl Trop Dis | pmid:19190730 |
| Chen CK et al. | Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. | 2010 | PLoS Negl Trop Dis | pmid:20386598 |
| Thomas JH | Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. | 2007 | PLoS Genet. | pmid:17500592 |
| Stottmann RW et al. | Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. | 2011 | PLoS Genet. | pmid:21912524 |
| Selmecki AM et al. | Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. | 2009 | PLoS Genet. | pmid:19876375 |
| Ma LJ et al. | Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. | 2009 | PLoS Genet. | pmid:19578406 |
| Iskar M et al. | Drug-induced regulation of target expression. | 2010 | PLoS Comput. Biol. | pmid:20838579 |
| Min BS et al. | Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. | 2001 | Planta Med. | pmid:11745016 |
| Yao X et al. | Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. | 2012 | Planta Med. | pmid:22961117 |
| Wang N et al. | Five new 3,4-seco-lanostane-type triterpenoids with antiproliferative activity in human leukemia cells isolated from the roots of Kadsura coccinea. | 2012 | Planta Med. | pmid:22948612 |