MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shapiro BE and Gealt MA | Ergosterol and lanosterol from Aspergillus nidulans. | 1982 | J. Gen. Microbiol. | pmid:7050295 |
Schroepfer GJ | Sterol biosynthesis. | 1982 | Annu. Rev. Biochem. | pmid:6810750 |
Kling D and Gamble W | Cholesterol biosynthesis in polychlorinated biphenyl-treated rats. | 1982 | Environ. Res. | pmid:6802634 |
Trzaskos JM et al. | Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report. | 1982 | Lipids | pmid:6806557 |
Sarkar CP and Cenedella RJ | Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. | 1982 | Lipids | pmid:6177997 |
Grinstead GF and Gaylor JL | Total enzymic synthesis of cholesterol from 4,4,14 alpha-trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol. Solubilization, resolution, and reconstitution of delta 7-sterol 5-desaturase. | 1982 | J. Biol. Chem. | pmid:6815183 |
Sato Y and Sonoda Y | [Metabolism of 27-nor-24,25-dihydrolanosterol and 23,24,25,26,27-pentanordihydrolanosterol by rat liver homogenate preparations]. | 1982 | Chem. Pharm. Bull. | pmid:7094149 |
Tiffany JM and Marsden RG | The meibomian lipids of the rabbit. II. Detailed composition of the principal esters. | 1982 | Exp. Eye Res. | pmid:7075715 |
Cenedella RJ | Digitonide precipitable sterols: a reevaluation with special attention to lanosterol. | 1982 | Lipids | pmid:7050581 |
Tint GS and Salen G | Biosynthesis of cholesterol, lanosterol, and delta 7-cholestenol, but not cholestanol, in cultured fibroblasts from normal individuals and patients with cerebrotendinous xanthomatosis. | 1982 | J. Lipid Res. | pmid:7097124 |