MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Alvarez-Vasquez F et al. | Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. | 2011 | PLoS ONE | pmid:22194828 |
Brumfield KM et al. | Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. | 2010 | PLoS ONE | pmid:20084111 |
Alvarez-Rueda N et al. | Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance. | 2011 | PLoS ONE | pmid:21698128 |
Cushion MT et al. | Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. | 2007 | PLoS ONE | pmid:17487271 |
Vinci G et al. | Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. | 2008 | PLoS ONE | pmid:18682733 |
Straud S et al. | Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. | 2010 | PLoS ONE | pmid:20661293 |
Chadwick W et al. | Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. | 2011 | PLoS ONE | pmid:21738745 |
Mullins JG et al. | Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola. | 2011 | PLoS ONE | pmid:21738598 |
Solberg R et al. | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. | 2010 | PLoS ONE | pmid:20231903 |
Chen CL et al. | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. | 2015 | PLoS ONE | pmid:26448474 |