MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cantu D et al. | Next generation sequencing provides rapid access to the genome of Puccinia striiformis f. sp. tritici, the causal agent of wheat stripe rust. | 2011 | PLoS ONE | pmid:21909385 |
Oliaro-Bosso S et al. | Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. | 2011 | PLoS ONE | pmid:21811565 |
Ngamskulrungroj P et al. | Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. | 2012 | PLoS ONE | pmid:22412978 |
Desnos-Ollivier M et al. | Antifungal susceptibility profiles of 1698 yeast reference strains revealing potential emerging human pathogens. | 2012 | PLoS ONE | pmid:22396754 |
Snelders E et al. | Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. | 2012 | PLoS ONE | pmid:22396740 |
Kosir R et al. | Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis. | 2012 | PLoS ONE | pmid:22384077 |
Morris TJ et al. | Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits. | 2009 | PLoS ONE | pmid:19787071 |
Willger SD et al. | A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. | 2008 | PLoS Pathog. | pmid:18989462 |
Mansfield BE et al. | Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. | 2010 | PLoS Pathog. | pmid:20941354 |
Singh SD et al. | Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. | 2009 | PLoS Pathog. | pmid:19649312 |