MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Valachovic M et al. | Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae. | 2001 | FEMS Microbiol. Lett. | pmid:11287144 |
Joubert BM et al. | Trypanosome and animal lanosterol synthases use different catalytic motifs. | 2001 | Org. Lett. | pmid:11405754 |
Charbonneau C et al. | The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy. | 2001 | Biophys. Chem. | pmid:11429202 |
Kushiro M et al. | Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11437378 |
Lindenthal B et al. | Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. | 2001 | J. Lipid Res. | pmid:11441136 |
Baltsen M et al. | Content of meiosis activating sterols in equine follicular fluids: correlation to follicular size and dominance. | 2001 | Theriogenology | pmid:11467509 |
Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
Becker K et al. | Identification of a novel mutation in 3beta-hydroxysteroid-Delta8-Delta7-isomerase in a case of Conradi-Hünermann-Happle syndrome. | 2001 | Exp. Dermatol. | pmid:11493318 |
Burger BV et al. | Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus. | 2001 | J. Chem. Ecol. | pmid:11504028 |
Jeong TM et al. | Sterols from a species of Pichia, a n-alkane-utilizing yeast. | 1975 | Steroids | pmid:1154452 |
Wang FS et al. | [Studies on the ganoderic acid, a new constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst]. | 1997 | Yao Xue Xue Bao | pmid:11596326 |
Ness GC et al. | Regulation of hepatic lanosterol 14 alpha-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents. | 2001 | Arch. Biochem. Biophys. | pmid:11697861 |
Milla P et al. | Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. | 2002 | J. Biol. Chem. | pmid:11706015 |
Hosoe T et al. | New pentanorlanostane derivatives, cladosporide B-D, as characteristic antifungal agents against Aspergillus fumigatus, isolated from Cladosporium sp. | 2001 | J. Antibiot. | pmid:11714232 |
Weber N et al. | Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya. | 2001 | J. Agric. Food Chem. | pmid:11714305 |
Podust LM et al. | Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51. | 2001 | J. Inorg. Biochem. | pmid:11744060 |
Min BS et al. | Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. | 2001 | Planta Med. | pmid:11745016 |
Roberti R et al. | Cloning and expression of sterol Delta 14-reductase from bovine liver. | 2002 | Eur. J. Biochem. | pmid:11784322 |
Ma J et al. | New lanostanoids from the mushroom Ganoderma lucidum. | 2002 | J. Nat. Prod. | pmid:11809071 |
Su HJ et al. | Lanostanoids of Amentotaxus formosana. | 2002 | J. Nat. Prod. | pmid:11809073 |