| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Neil HA et al. | Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. | 2010 | Atherosclerosis | pmid:21036355 |
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |
| Ponmanickam P et al. | Identification of testosterone-dependent volatile compounds and proteins in the preputial gland of rat Rattus norvegicus. | 2010 | Gen. Comp. Endocrinol. | pmid:20211182 |
| Martinez-Seara H et al. | Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes. | 2010 | PLoS ONE | pmid:20567600 |
| Wang F et al. | Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20193772 |
| Urzúa U et al. | Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis. | 2010 | BMC Genomics | pmid:21210965 |
| Zhang YQ et al. | Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. | 2010 | PLoS Pathog. | pmid:20532216 |
| Sun C et al. | De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. | 2010 | BMC Genomics | pmid:20416102 |
| Rani S et al. | Phytochemical investigation of the seeds of Althea officinalis L. | 2010 | Nat. Prod. Res. | pmid:20803381 |
| Feng LJ et al. | Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene. | 2010 | Chin. Med. J. | pmid:20367978 |
| Xu Y et al. | Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20362444 |
| Lu X et al. | Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. | 2010 | J. Sci. Food Agric. | pmid:20355042 |
| Lee CH et al. | Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea. | 2010 | J. Agric. Food Chem. | pmid:20334412 |
| Morio F et al. | Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. | 2010 | Diagn. Microbiol. Infect. Dis. | pmid:20226328 |
| Ren A et al. | Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum. | 2010 | Bioresour. Technol. | pmid:20395130 |
| Targett-Adams P et al. | Lipid metabolism and HCV infection. | 2010 | Viruses | pmid:21994676 |
| Taramino S et al. | Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. | 2010 | Biochim. Biophys. Acta | pmid:19879375 |
| Chandrasekar SB et al. | Phytopharmacology of Ficus religiosa. | 2010 | Pharmacogn Rev | pmid:22228961 |
| Mantzouridou F and Tsimidou MZ | Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. | 2010 | FEMS Yeast Res. | pmid:20550581 |
| Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
| Serra M et al. | Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20804844 |
| Andreyev AY et al. | Subcellular organelle lipidomics in TLR-4-activated macrophages. | 2010 | J. Lipid Res. | pmid:20574076 |
| Kim JH et al. | Changes in cholesterol biosynthetic and transport pathways after excitotoxicity. | 2010 | J. Neurochem. | pmid:19860851 |
| Shi L et al. | Current progress in the study on biosynthesis and regulation of ganoderic acids. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20859739 |
| Cicek SS et al. | Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. | 2010 | J. Nat. Prod. | pmid:21082802 |
| Taramino S et al. | Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. | 2010 | Biochim. Biophys. Acta | pmid:20659585 |
| Straud S et al. | Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. | 2010 | PLoS ONE | pmid:20661293 |
| Kaneshiro ES | Biochemical research elucidating metabolic pathways in Pneumocystis. | 2010 | Parasite | pmid:21275234 |
| Aono T et al. | Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials. | 2010 | J. Biomed. Sci. | pmid:21129218 |
| Zoller E et al. | Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections. | 2010 | Drug Des Devel Ther | pmid:21116336 |
| Chung MJ et al. | Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. | 2010 | Nutr Res Pract | pmid:20607061 |
| Zhu J et al. | Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake. | 2010 | J. Lipid Res. | pmid:20037138 |
| Zhu LW and Tang YJ | Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides during the fermentation of Ganoderma lucidum. | 2010 | Bioprocess Biosyst Eng | pmid:20369259 |
| Sundar S and Chakravarty J | Liposomal amphotericin B and leishmaniasis: dose and response. | 2010 | J Glob Infect Dis | pmid:20606972 |
| Yang XW et al. | Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr. | 2010 | Org. Biomol. Chem. | pmid:20372737 |
| Guan W et al. | Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen. | 2010 | PLoS ONE | pmid:20593017 |
| Domitrovic T et al. | Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. | 2010 | PLoS ONE | pmid:20567505 |
| Owens CM et al. | Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication. | 2010 | Mol. Syst. Biol. | pmid:20531405 |
| Weete JD et al. | Phylogenetic distribution of fungal sterols. | 2010 | PLoS ONE | pmid:20526375 |
| Fatmawati S et al. | Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum. | 2010 | Planta Med. | pmid:20379959 |
| Hu J et al. | Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. | 2010 | Nutr Metab (Lond) | pmid:20515451 |
| Adams M et al. | Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. | 2010 | J. Nat. Prod. | pmid:20384295 |
| Al-Badriyeh D et al. | Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. | 2010 | Clin Ophthalmol | pmid:20463910 |
| Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. | 2010 | Clin. Sci. | pmid:20443782 |
| Kraus JM et al. | Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. | 2010 | J. Med. Chem. | pmid:20429511 |
| Zhang WX et al. | Impact of oxygen level in gaseous phase on gene transcription and ganoderic acid biosynthesis in liquid static cultures of Ganoderma lucidum. | 2010 | Bioprocess Biosyst Eng | pmid:19809834 |
| Musaji N | Antifungal drug resistance: not all azoles are equal. | 2010 | Expert Rev Anti Infect Ther | pmid:20455680 |
| Carland F et al. | The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products. | 2010 | Plant Physiol. | pmid:20421456 |
| Xu JW et al. | Biotechnological production and application of ganoderic acids. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20437236 |
| Pereira M et al. | Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis. | 2010 | Biochim. Biophys. Acta | pmid:20624480 |
| Warrilow AG et al. | Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. | 2010 | Antimicrob. Agents Chemother. | pmid:20660663 |
| Vazquez JA | Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection. | 2010 | HIV AIDS (Auckl) | pmid:22096388 |
| Liang CX et al. | Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20077112 |
| Ianas V et al. | Role of posaconazole in the treatment of oropharyngeal candidiasis. | 2010 | Infect Drug Resist | pmid:21694893 |
| Sharma A et al. | Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice. | 2010 | Libyan J Med | pmid:21483544 |
| Lee I et al. | Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells. | 2010 | J. Nat. Prod. | pmid:20039640 |
| Bennassar A and Grimalt R | Management of tinea capitis in childhood. | 2010 | Clin Cosmet Investig Dermatol | pmid:21437064 |
| Modica S et al. | Deciphering the nuclear bile acid receptor FXR paradigm. | 2010 | Nucl Recept Signal | pmid:21383957 |
| Fon Tacer K et al. | Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206258 |
| Che S et al. | [RP-HPLC simultaneous determination of five triterpenoid acids in different parts of Poria cocos by UV wavelengths switch]. | 2010 | Yao Xue Xue Bao | pmid:21355217 |
| Pérez-Castrillón JL et al. | Vitamin d levels and lipid response to atorvastatin. | 2010 | Int J Endocrinol | pmid:20016682 |
| Joffrion TM et al. | Functional characterization and localization of Pneumocystis carinii lanosterol synthase. | 2010 | Eukaryotic Cell | pmid:19897737 |
| Wyder MA et al. | Clearance in vivo of instilled [h]cholesterol from the rat lung. | 2010 | Biochem Res Int | pmid:21188079 |
| Xu Y et al. | Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. | 2009 | Respir. Res. | pmid:19344509 |
| Brannian J et al. | Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. | 2009 | J Ovarian Res | pmid:19650929 |
| Wang W et al. | Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives. | 2009 | Arch. Pharm. (Weinheim) | pmid:19899102 |
| Wang W et al. | Discovery of highly potent novel antifungal azoles by structure-based rational design. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19748782 |
| Livanec PW et al. | Exploring the effects of sterols in model lipid membranes using single-molecule orientations. | 2009 | J Phys Chem B | pmid:19572622 |
| Che X et al. | New azoles with potent antifungal activity: design, synthesis and molecular docking. | 2009 | Eur J Med Chem | pmid:19539408 |
| Godio RP and MartÃn JF | Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. | 2009 | Fungal Genet. Biol. | pmid:19130892 |
| Sen K and Hackett JC | Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis. | 2009 | J Phys Chem B | pmid:19438188 |
| Lintker KB et al. | A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films. | 2009 | Chem. Phys. Lipids | pmid:19524563 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Sánchez-Wandelmer J et al. | Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes. | 2009 | Biochim. Biophys. Acta | pmid:19433058 |
| Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |
| Büdefeld T et al. | Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. | 2009 | Anat Histol Embryol | pmid:19793088 |
| Nes WD et al. | Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. | 2009 | Arch. Biochem. Biophys. | pmid:19014901 |
| Monostory K et al. | Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent. | 2009 | Drug Metab. Dispos. | pmid:18971317 |
| Acimovic J et al. | Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19525158 |
| Lee JH et al. | Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes. | 2009 | Eur. J. Pharmacol. | pmid:19446542 |
| Bean TP et al. | Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides. | 2009 | FEMS Microbiol. Lett. | pmid:19459949 |
| Majid E et al. | Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata. | 2009 | Electrophoresis | pmid:19517437 |
| Deng JY et al. | Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas. | 2009 | Chem. Res. Toxicol. | pmid:19848398 |
| Madoui MA et al. | Sterol metabolism in the oomycete Aphanomyces euteiches, a legume root pathogen. | 2009 | New Phytol. | pmid:19496952 |
| Elfita E et al. | Antiplasmodial and other constituents from four Indonesian Garcinia spp. | 2009 | Phytochemistry | pmid:19481231 |
| Wang GJ et al. | Lanostanes from Phellinus igniarius and their iNOS inhibitory activities. | 2009 | Planta Med. | pmid:19557671 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Zhang Q et al. | Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. | 2009 | J Nat Med | pmid:19407927 |
| Ishida K et al. | Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms. | 2009 | BMC Microbiol. | pmid:19379501 |
| Ader F et al. | Management of invasive aspergillosis in patients with COPD: rational use of voriconazole. | 2009 | Int J Chron Obstruct Pulmon Dis | pmid:19684861 |
| Wang H et al. | Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing. | 2009 | BMC Microbiol. | pmid:19682357 |
| Pires AB et al. | Early development of Moniliophthora perniciosa basidiomata and developmentally regulated genes. | 2009 | BMC Microbiol. | pmid:19653910 |
| Singh SD et al. | Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. | 2009 | PLoS Pathog. | pmid:19649312 |
| Wu J et al. | Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia. | 2009 | BMC Mol. Biol. | pmid:19646271 |
| Howard SJ et al. | Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. | 2009 | Emerging Infect. Dis. | pmid:19624922 |
| Ma LJ et al. | Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. | 2009 | PLoS Genet. | pmid:19578406 |
| Doyle MA et al. | LeishCyc: a biochemical pathways database for Leishmania major. | 2009 | BMC Syst Biol | pmid:19497128 |
| Suryadevara PK et al. | Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease. | 2009 | J. Med. Chem. | pmid:19463001 |
| Wang C et al. | Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro. | 2009 | J. Lipid Res. | pmid:19433477 |