MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lanosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Xanthomatosis | D014973 | 17 associated lipids |
Abetalipoproteinemia | D000012 | 7 associated lipids |
Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Levine L | Nuclear receptor agonists stimulate release of arachidonic acid from rat liver cells. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468267 |
Liu XY et al. | Creating new supramolecular materials by architecture of three-dimensional nanocrystal fiber networks. | 2002 | J. Am. Chem. Soc. | pmid:12475350 |
Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
Xiao YQ et al. | [Studies on quality specification standards for Saposhnicovia divaricata (Turcz.) Schischk]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12525039 |
Hess BA | Formation of the C ring in the lanosterol biosynthesis from squalene. | 2003 | Org. Lett. | pmid:12529131 |
Otte K et al. | Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. | 2003 | Mol. Cell. Biol. | pmid:12529392 |
Kaneshiro ES | Sterol biosynthesis in Pneumocystis: unique steps that define unique targets. | 2002 | Drug Resist. Updat. | pmid:12531182 |
Porter TD | Supernatant protein factor and tocopherol-associated protein: an unexpected link between cholesterol synthesis and vitamin E (review). | 2003 | J. Nutr. Biochem. | pmid:12559471 |
Majumder PL et al. | Triterpenoids from the orchids Agrostophyllum brevipes and Agrostophyllum callosum. | 2003 | Phytochemistry | pmid:12560031 |
Jackson CJ et al. | Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565899 |
Ji H et al. | Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi. | 2003 | J. Med. Chem. | pmid:12570370 |
Luo J and Lin ZB | [A new triterpene from the fruiting bodies of Ganoderma lucidum]. | 2001 | Yao Xue Xue Bao | pmid:12579936 |
Kawagishi H et al. | Novel hydroquinone as a matrix metallo-proteinase inhibitor from the mushroom, Piptoporus betulinus. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596882 |
Morales IJ et al. | Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12606318 |
Yamashita Y et al. | Production of progesterone from de novo-synthesized cholesterol in cumulus cells and its physiological role during meiotic resumption of porcine oocytes. | 2003 | Biol. Reprod. | pmid:12606468 |
Sakurai N et al. | Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. | 2003 | Bioorg. Med. Chem. | pmid:12614901 |
Rozenberg O et al. | Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615663 |
Gibbons GF | The role of cytochrome P450 in the regulation of cholesterol biosynthesis. | 2002 | Lipids | pmid:12617470 |
Zhou W et al. | Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii. | 2002 | Lipids | pmid:12617472 |