| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang TH et al. | Effect of cholesterol and lanosterol on the structure and dynamics of the cell membrane of Mycoplasma capricolum. Deuterium nuclear magnetic resonance study. | 1991 | Biophys. J. | pmid:2049526 |
| Gylling H et al. | Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. | 1991 | Metab. Clin. Exp. | pmid:1984567 |
| Hashimoto F and Hayashi H | Identification of intermediates after inhibition of cholesterol synthesis by aminotriazole treatment in vivo. | 1991 | Biochim. Biophys. Acta | pmid:1954238 |
| Barrett-Bee K et al. | Biochemical changes associated with the antifungal action of the triazole ICI 153,066 on Candida albicans and Trichophyton quinckeanum. | 1991 | FEMS Microbiol. Lett. | pmid:2060756 |
| Nes WD et al. | Regulation of sterol biosynthesis in sunflower by 24(R,S),25-epiminolanosterol, a novel C-24 methyl transferase inhibitor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2043140 |
| Tuck SF et al. | Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. | 1991 | J. Lipid Res. | pmid:1940622 |
| Mayer RJ et al. | Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells. | 1991 | J. Biol. Chem. | pmid:1657912 |
| Lange Y | Disposition of intracellular cholesterol in human fibroblasts. | 1991 | J. Lipid Res. | pmid:2066666 |
| Sonoda Y et al. | Synthesis of lanosterol derivatives with a functional group at C-32, including an antineoplastic sterol, 3 beta-hydroxylanost-7-en-32-oic acid. | 1991 | Chem. Pharm. Bull. | pmid:2049792 |
| Nes WD et al. | Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase. | 1991 | J. Biol. Chem. | pmid:1869550 |
| Aoyama Y and Yoshida Y | Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872829 |
| Wright GD and Honek JF | Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222. | 1991 | J. Bacteriol. | pmid:1846852 |
| Wang CN et al. | The inhibition of human platelet function by ganodermic acids. | 1991 | Biochem. J. | pmid:1649599 |
| Aoyama Y et al. | Role of the side chain of lanosterol in substrate recognition and catalytic activity of lanosterol 14 alpha-demethylase (cytochrome P-450 (14DM)) of yeast. | 1991 | Biochim. Biophys. Acta | pmid:1998745 |
| Lee SS et al. | Application of modern NMR techniques in the structure determination of microbial transformation products from sterols. | 1991 | Proc. Natl. Sci. Counc. Repub. China B | pmid:1946817 |
| Chen RY and Yu DQ | [Studies on the triterpenoid constituents of the spores from Ganoderma lucidum karst]. | 1991 | Yao Xue Xue Bao | pmid:1957672 |
| Aoyama Y et al. | Structural analysis of the interaction between the side-chain of substrates and the active site of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast. | 1992 | Biochim. Biophys. Acta | pmid:1504086 |
| Pfaller M and Riley J | Effects of fluconazole on the sterol and carbohydrate composition of four species of Candida. | 1992 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:1396728 |
| Loper JC | Cytochrome P450 lanosterol 14α-demethylase (CYP51): insights from molecular genetic analysis of the ERG11 gene in Saccharomyces cerevisiae. | 1992 | J. Steroid Biochem. Mol. Biol. | pmid:22217856 |
| Buttke TM and Folks TM | Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation. | 1992 | J. Biol. Chem. | pmid:1577721 |
| Aoki Y et al. | A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. II. Mode of action. | 1992 | J. Antibiot. | pmid:1556007 |
| Rahier A and Taton M | Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14 alpha-demethylase. | 1992 | Biochim. Biophys. Acta | pmid:1571366 |
| Weber JM et al. | Factors affecting homologous overexpression of the Saccharomyces cerevisiae lanosterol 14 alpha-demethylase gene. | 1992 | Yeast | pmid:1523885 |
| Panini SR et al. | Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol. | 1992 | J. Biol. Chem. | pmid:1618770 |
| Arce V et al. | A comparative study of the in vitro and in vivo formation of lanosterol derivatives from acetate by different chick tissues. | 1993 | Biochem. Mol. Biol. Int. | pmid:8330018 |
| Mimaki Y et al. | Lanosterol and 27-norlanosterol oligosaccharides from the bulbs of Chionodoxa gigantea. | 1993 | Phytochemistry | pmid:7764152 |
| Mercer EI | Inhibitors of sterol biosynthesis and their applications. | 1993 | Prog. Lipid Res. | pmid:8309949 |
| Seo S et al. | Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. | 1993 | Steroids | pmid:8484187 |
| Vanden Bossche H et al. | Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. | 1993 | Antimicrob. Agents Chemother. | pmid:8257130 |
| Sonoda Y et al. | Purification of a human cytochrome P-450 isozyme catalyzing lanosterol 14 alpha-demethylation. | 1993 | Biochim. Biophys. Acta | pmid:8399332 |
| Koukkou AI et al. | Effect of ethanol on the sterols of the fission yeast Schizosaccharomyces pombe. | 1993 | FEMS Microbiol. Lett. | pmid:8405927 |
| Trzaskos JM et al. | Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis. | 1993 | J. Biol. Chem. | pmid:7693673 |
| Bühler H et al. | Endogenous inhibitors of 11 beta-OHSD: existence and possible significance. | 1994 | Steroids | pmid:8191542 |
| Buttke TM and Van Cleave S | Adaptation of a cholesterol deficient human T cell line to growth with lanosterol. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8166689 |
| Leonard DA et al. | Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 3 beta-hydroxy-lanost-8-en-32-al, an intermediate in the conversion of lanosterol to cholesterol. | 1994 | Arch. Biochem. Biophys. | pmid:8161198 |
| Mimaki Y et al. | Lanosterol oligosaccharides from the plants of the subfamily Scilloideae and their antitumor-promoter activity. | 1994 | Chem. Pharm. Bull. | pmid:8149459 |
| Izumi A et al. | Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology. | 1994 | J. Lipid Res. | pmid:7964186 |
| Fujimoto H et al. | Isolation and characterization of immunosuppressive components of three mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina. | 1994 | Chem. Pharm. Bull. | pmid:8004718 |
| Frye LL et al. | Oxolanosterol oximes: dual-action inhibitors of cholesterol biosynthesis. | 1994 | J. Lipid Res. | pmid:7989858 |
| Hashimoto F and Hayashi H | Peroxisomal cholesterol synthesis in vivo: accumulation of 4-methyl intermediate sterols after aminotriazole inhibition of cholesterol synthesis. | 1994 | Biochim. Biophys. Acta | pmid:8068723 |
| Sekigawa Y et al. | Purification and characterization of a cytochrome P450 isozyme catalyzing lanosterol 14 alpha-demethylation (P45014DM) in hamster liver. | 1995 | Lipids | pmid:8614296 |
| Kerr RG and Chen Z | In vivo and in vitro biosynthesis of saponins in sea cucumbers. | 1995 | J. Nat. Prod. | pmid:7769386 |
| Lees ND et al. | Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. | 1995 | Lipids | pmid:7791529 |
| Abe I and Prestwich GD | Identification of the active site of vertebrate oxidosqualene cyclase. | 1995 | Lipids | pmid:7791531 |
| Anderson JA et al. | 15-substituted lanosterols: post-transcriptional suppressors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 1995 | Arch. Biochem. Biophys. | pmid:7840615 |
| Harmouch N et al. | Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus. | 1995 | FEMS Microbiol. Lett. | pmid:8586261 |
| Takei M et al. | Mechanism of inhibition of IgE-dependent histamine release from rat mast cells by penasterol and penasterone. | 1995 | J Pharm Sci | pmid:7537812 |
| Koeda M et al. | Studies on the Chinese crude drug "shoma." IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from cimicifuga rhizome. | 1995 | Chem. Pharm. Bull. | pmid:7553963 |
| Venkateswarlu K et al. | Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug. | 1995 | FEMS Microbiol. Lett. | pmid:7557345 |
| Trzaskos JM et al. | Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: II. Time-dependent enzyme inactivation by selected oxylanosterol analogs. | 1995 | Biochemistry | pmid:7626637 |