| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pan RL et al. | Two new cyclolanostanol glycosides from the aerial parts of Cimicifuga foetida. | 2004 | J Asian Nat Prod Res | pmid:14989382 |
| Zhao XH et al. | [Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015286 |
| Pan RL et al. | [Studies on the new triterpenoid saponin of the aerial part of Cimicifuga foetida]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015306 |
| Abe I et al. | Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15025461 |
| Lepesheva GI and Waterman MR | CYP51--the omnipotent P450. | 2004 | Mol. Cell. Endocrinol. | pmid:15026190 |
| Ye X et al. | Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. | 2004 | Mol. Biol. Rep. | pmid:15040456 |
| Aoyama Y et al. | Structural analysis of the interaction between the side-chain of substrates and the active site of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast. | 1992 | Biochim. Biophys. Acta | pmid:1504086 |
| Zuckermann MJ et al. | Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts. | 2004 | Meth. Enzymol. | pmid:15063652 |
| Jabra-Rizk MA et al. | Fungal biofilms and drug resistance. | 2004 | Emerging Infect. Dis. | pmid:15078591 |
| Nöllmann M et al. | The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. | 2004 | Biophys. J. | pmid:15111427 |
| Xie H et al. | Roles of gonadotropins and meiosis-activating sterols in meiotic resumption of cultured follicle-enclosed mouse oocytes. | 2004 | Mol. Cell. Endocrinol. | pmid:15130520 |
| Martin-Creuzburg D and Von Elert E | Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. | 2004 | J. Chem. Ecol. | pmid:15139303 |
| Chen YG et al. | Ananosic acids B and C, two new 18(13-->12)-abeo-lanostane triterpenoids from Kadsura ananosma. | 2004 | J. Nat. Prod. | pmid:15165154 |
| Moodley N et al. | Eucosterol-type nortriterpenoids from Merwilla natalensis. | 2004 | J. Nat. Prod. | pmid:15165167 |
| Kavtaradze LK et al. | Efficient routes to epimerically-pure side-chain derivatives of lanosterol. | 2004 | Steroids | pmid:15183688 |
| Dantas-Leite L et al. | Selective anti-Toxoplasma gondii activities of azasterols. | 2004 | Int. J. Antimicrob. Agents | pmid:15194134 |
| Barker KS et al. | Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans. | 2004 | J. Antimicrob. Chemother. | pmid:15201233 |
| Sheng C et al. | Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate Interactions. | 2004 | J. Biomol. Struct. Dyn. | pmid:15214809 |
| Henriksen J et al. | Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity. | 2004 | Eur. Biophys. J. | pmid:15221234 |
| Weber JM et al. | Factors affecting homologous overexpression of the Saccharomyces cerevisiae lanosterol 14 alpha-demethylase gene. | 1992 | Yeast | pmid:1523885 |