| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huster D et al. | Desmosterol may replace cholesterol in lipid membranes. | 2005 | Biophys. J. | pmid:15596512 |
| Prasad R and Kapoor K | Multidrug resistance in yeast Candida. | 2005 | Int. Rev. Cytol. | pmid:15598470 |
| Harwood HJ et al. | Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase. | 2005 | J. Lipid Res. | pmid:15604516 |
| León F et al. | Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells. | 2004 | J. Nat. Prod. | pmid:15620242 |
| Vieira LM et al. | Bioactive friedolanostanes and 11(10-->8)-abeolanostanes from the bark of Garcinia speciosa. | 2004 | J. Nat. Prod. | pmid:15620248 |
| Kuroda M et al. | 27-norlanostane glycosides from the bulbs of Muscari paradoxum. | 2004 | J. Nat. Prod. | pmid:15620262 |
| Hajjaj H et al. | Aspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol. | 2005 | FEMS Microbiol. Lett. | pmid:15621432 |
| Kaneshiro ES | Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights. | 2004 | Lipids | pmid:15638243 |
| Kudo M et al. | Studies on the expression levels of sterol-metabolizing enzymes in the obese model SHR/NDmcr-cp rats. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15649292 |
| Dantas-Leite L et al. | Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii. | 2005 | Int. J. Antimicrob. Agents | pmid:15664482 |
| Sakurai N et al. | Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds. | 2005 | Bioorg. Med. Chem. | pmid:15670948 |
| Yoshikawa K et al. | Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2. | 2005 | J. Nat. Prod. | pmid:15679320 |
| Wangun HV et al. | Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus. | 2004 | J. Antibiot. | pmid:15712671 |
| Rahier A and Taton M | Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14 alpha-demethylase. | 1992 | Biochim. Biophys. Acta | pmid:1571366 |
| Mouritsen OG and Zuckermann MJ | What's so special about cholesterol? | 2004 | Lipids | pmid:15726825 |
| Clarenbach JJ et al. | Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis. | 2005 | Metab. Clin. Exp. | pmid:15736111 |
| Stocker A | Molecular mechanisms of vitamin E transport. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753133 |
| Liu Y et al. | Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. | 2005 | Mol. Endocrinol. | pmid:15761033 |
| Venteclef N et al. | The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity. | 2005 | Biochem. Pharmacol. | pmid:15763540 |
| Hildenbrand MF and Bayerl TM | Differences in the modulation of collective membrane motions by ergosterol, lanosterol, and cholesterol: a dynamic light scattering study. | 2005 | Biophys. J. | pmid:15764657 |