lanosterol

lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lanosterol?

lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lanosterol

MeSH term MeSH ID Detail
Abetalipoproteinemia D000012 7 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Xanthomatosis D014973 17 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with lanosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lanosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lanosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with lanosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lanosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lanosterol?

Knock-out

Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with lanosterol

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Authors Title Published Journal PubMed Link
Chen HW and Leonard DA Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. 1984 J. Biol. Chem. pmid:6429139
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Theesfeld CL and Hampton RY Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. 2013 J. Biol. Chem. pmid:23306196
KANDUTSCH AA and RUSSELL AE Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol. 1960 J. Biol. Chem. pmid:14404284
Keber R et al. Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. 2011 J. Biol. Chem. pmid:21705796
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GAUTSCHI F and BLOCH K Synthesis of isomeric 4,4-dimethylcholestenols and identification of a lanosterol metabolite. 1958 J. Biol. Chem. pmid:13610839
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Shichiri M et al. A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity. 2012 J. Biol. Chem. pmid:22147702
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Buttke TM and Folks TM Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation. 1992 J. Biol. Chem. pmid:1577721
Popják G et al. Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells. 1989 J. Biol. Chem. pmid:2703486
Ramsey RB et al. Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. 1972 J. Biol. Chem. pmid:5030627
Wang Y et al. Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha. 2008 J. Biol. Chem. pmid:18676367
D'Agostino J et al. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes. 2012 J. Biol. Chem. pmid:22453923
Polito A et al. Artificial substrates in squalene and sterol biosynthesis. 1972 J. Biol. Chem. pmid:4337856
Malhotra HC and Nes WR The conversion of mevalonate to 24-methylenecycloartanol by a cell-free enzyme preparation from nonphotosynthetic tissue. 1972 J. Biol. Chem. pmid:4651646
Mayer RJ et al. Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells. 1991 J. Biol. Chem. pmid:1657912
Milla P et al. Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. 2002 J. Biol. Chem. pmid:11706015
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Shi J et al. Identification and characterization of an S-adenosyl-L-methionine: delta 24-sterol-C-methyltransferase cDNA from soybean. 1996 J. Biol. Chem. pmid:8621604
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Yoshida Y and Aoyama Y Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties. 1984 J. Biol. Chem. pmid:6363414
Aoyama Y et al. Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes. 1984 J. Biol. Chem. pmid:6420412
Grinstead GF and Gaylor JL Total enzymic synthesis of cholesterol from 4,4,14 alpha-trimethyl-5 alpha-cholesta-8,24-dien-3 beta-ol. Solubilization, resolution, and reconstitution of delta 7-sterol 5-desaturase. 1982 J. Biol. Chem. pmid:6815183
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Aoyama Y et al. Altered cytochrome P-450 in a yeast mutant blocked in demethylating C-32 of lanosterol. 1983 J. Biol. Chem. pmid:6409899
Aoyama Y et al. Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation. 1989 J. Biol. Chem. pmid:2509459
LINDBERG M et al. Ketonic intermediates in the demethylation of lanosterol. 1963 J. Biol. Chem. pmid:13930748
Paik YK et al. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. 1986 J. Biol. Chem. pmid:2422166
Noland BJ et al. Purification and properties of sterol carrier protein2. 1980 J. Biol. Chem. pmid:7372677
Aoyama Y et al. Isolation and characterization of an altered cytochrome P-450 from a yeast mutant defective in lanosterol 14 alpha-demethylation. 1987 J. Biol. Chem. pmid:3115990
Chang TY et al. Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor. 1979 J. Biol. Chem. pmid:500643
Panini SR et al. Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol. 1992 J. Biol. Chem. pmid:1618770
Paik YK et al. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. 1984 J. Biol. Chem. pmid:6444198
Boesze-Battaglia K et al. Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. 2009 J. Biol. Chem. pmid:19240023
Hughes AL et al. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. 2007 J. Biol. Chem. pmid:17595166